latest Prof.Dr. Yong Poovorawan Head of the Center of Excellence in Clinical Virology Department of Pediatrics Faculty of Medicine Chulalongkorn University states that
COVID-19 Vaccine Immunity caused by vaccination compared to infection
It is of great interest to study
The infection has a chance of being seriously ill and hospitalized. than the side effects of the vaccine
vaccine-induced immunity measured at doses much higher than infectious
Because it uses a large amount of antigens, especially mRNA.
Infection in nature can build immunity well.
From a study in America (Journal of American Journal of Public Health, 2023;113:96-104) there is interesting data.
Those who received the vaccine and those who were infected after a long period of follow-up.
It was found that those who were vaccinated have a higher chance of being infected than those who were previously infected
the severity of the disease in persons with re-infection with those infected after vaccination. found to be opposite
Those who are reinfected or infected after the initial infection are more severe. people infected after vaccination
That is, the patient is hospitalized. Serious illness or death than those who have been vaccinated and are infected
This information shows the importance of vaccination.
even if already infected There is a reason to receive the vaccine in the next dose.
by leaving a reasonable period of time after infection especially for more than 6 months
medical genome center Ramathibodi Hospital post a message about COVID-19 vaccine, stating that “the effectiveness of “Booster vaccine”, the second generation of mRNA “bivalent” from practical use in a population of more than 50,000 people to prevent infection with COVID-19 Update 27/12/2022 time 10: 05
Dr. Nabin K Shrestha and the infectious disease research team from the Cleveland Clinic which is a not-for-profit educational medical center. Located in Cleveland, Ohio, USA. presented research (prepare for publication) This is new research that has not been evaluated by an expert/peer review panel and should not be used as a guide to clinical practice.) Based on real world data of injections. “Bivalent Vaccine Booster Shot, second generation mRNA booster shot,” was collected from 51,011 working-age workers (mean age 42.3 years) of the “Cleveland Clinic.”
who received the first mRNA vaccine and was infected with COVID-19 natural before Between December 2020-2022, it was found that when receiving a second-generation mRNA vaccine, bivalent (bivalent Vaccine Booster Shot), starting from September 12, 2022, it can stimulate immunity that is effective in preventing infection. COVID-19 30% in 3 months
By that time, Ohio and neighboring states There have been outbreaks of emerging subspecies of omikron BQ.1.1, BQ.1, BA.5,XBB,BF.7, BN.1, and BA.2.75, with these strains occurring last week. as a percentage 40.7,28.9,8.9,6.2,5.8,4.2 and 1.3 respectively
But what was unexpected that the research team found is the risk of infection with COVID-19 Instead, there was a direct variation in the number or dose (dose) of vaccination (mRNA), that is, if a large number of mRNA vaccines had previously been received. The risk of contracting COVID-19 will be even higher Those who received three or more doses of the vaccine had a six-fold increase in the ‘risk’ of contracting COVID-19 compared to those who were not vaccinated. 
This study is not the first study. (It has been shown that high doses of the mRNA vaccine increase the risk of contracting COVID-19), but there is also a previous study that collected data from hundreds of thousands of volunteers in the country. Qatar found that people who received three doses of the mRNA vaccine had a higher risk of reinfection with Omicron than those who received two doses of the vaccine. Two or three doses of mRNA vaccine were associated with a higher risk of reinfection than those receiving a single mRNA vaccine.
These findings may suggest that vaccination stimulates the body to build immunity using specific strains of COVID. Narrow-Spectrum Anti-coronavirus Vaccines Imprinted SARS-CoV-2 humoral immunity only to capture and destroy this strain. The resulting immunity may be impaired if those individuals receive a repeat booster shot of the same strain of virus. and later re-infection (breakthrough SARS-CoV-2 infection) with emerging strains of COVID with different mutations These findings do not preclude the short-term benefit of booster vaccination.
Especially Group 608, but instead it is a catalyst for experts around the world to realize and pay attention to studying the human immune system when stimulated by vaccines or from complex natural infections. dimensions to obtain clear conclusions about the management of vaccine types Number of times (dose) of vaccination including injection distance It will also catalyze the development of a vaccine that can prevent infections that cover the original strain. The current epidemic species and new species that will emerge in the future (Broad-Spectrum Anti-coronavirus Vaccines) to ensure that vaccinated people receive the efficacy of each type of vaccine in preventing COVID-19 infection.
Finally, it must not be forgotten that the “risk” of severe infection or even death from COVID-19 The world is greatly reduced by vaccination.
Effectiveness of the Coronavirus Disease 2019 (COVID-19) Bivalent Vaccine. Available at:
https://www.medrxiv.org/con…/10.1101/2022.12.17.22283625v1
Chemaitelly H, Ayoub HH, Tang P, et al. COVID-19 primary series and booster vaccination and immune imprinting. 2022:2022.10.31.22281756. Chemaitelly H, Ayoub HH, Tang P, et al. COVID-19 primary series and booster vaccination and immune imprinting. 2022:2022.10.31.22281756. Available at: https://www.medrxiv.org/con…/10.1101/2022.10.31.22281756v1
Shrestha NK, Shrestha P, Burke PC, Nowacki AS, Terpeluk P, Gordon SM. Coronavirus Disease 2019 Vaccine Boosting in Previously Infected or Vaccinated Individuals (COVID-19). Clin Infect Dis 2022; :ciac327.”
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