Migraine is one of the most common primary headache disorders, and is a known risk factor for cardiovascular disorders. In a study whose findings were published in the journal ‘Cardiovascular Diabetology’, the researchers aimed to investigate the relationship between migraine and significant cardiovascular outcomes, including myocardial infarction (MI), ischemic stroke (IS) and cardiovascular mortality (CVD) among type 2 diabetic patients.
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For this purpose, the researchers used the Korean National Health Insurance Service database to collect information on 2,229,598 patients with type 2 diabetes and no previous history of MI or IS. In addition, the researchers identified patients over the age of 20 who suffer from migraine using claim data according to the International Statistical Classification of Diseases Related Health Problems, in its tenth edition (ICD-10), with the code G43. The patients suffering from migraine were divided according to the aura status of the migraine.
The migraine rate in the study population as a whole was 6.3%. The rate of MI cases,JIS,JCVD and all-cause mortality were 2.6%, 3.6%, 5.9%, and 7.9%, respectively. A diagnosis of migraine was significantly associated with an increased risk of MI events,JIS and CVD. The results remained significant after adjusting for variables including age, sex, body mass index, alcohol consumption, smoking habits, physical activity, economic status, history of hypertension, dyslipidemia, and duration of type 2 diabetes (MI, standardized hazard ratio: 1.182, bar profit -95% confidence: 1.146-1.219; IS, standardized hazard ratio: 1.111, 95% confidence interval 1.082-1.14; CVD, standardized hazard ratio 1.143, 95% confidence interval 1.12-1.167). It was also found that when comparing the migraine groups, migraine with aura was associated with an even higher risk of developing MI compared to migraine without aura. This difference becomes especially pronounced with age.
In conclusion, in the national population-based study conducted by the researchers, it was found that type 2 diabetes patients who suffer from migraines are at a distinctly high risk of having significant cardiovascular events, including MI,JIS, and CVD. The risk of MI and CVD increased significantly in the presence of aura symptoms among the patients with migraines.
source:
Cheon, D.Y., Han, K., Yang, Y.S. et al. Associations between migraine and major cardiovascular events in type 2 diabetes mellitus. Cardiovasc Diabetol 21, 275 (2022). https://doi.org/10.1186/s12933-022-01705-3