patients with diabetes have to use insulin for glucose to perform its function properly. Although it is a medicine worn by many, little is known about its origin.
Although insulin is currently created with biotechnology, for a long time its origin was another. The pig pancreas and cows served to be able to have this essential medicine in patients with diabetes.
The insulin It was discovered between 1921 and 1922 and has helped people with diabetes ever since to keep their bodies from having high blood glucose levels, he says. Nemours Children ‘s Health.
how is it obtained the insuline
Insulin is a hormones naturally produced by the pancreas, but can also be obtained by recombinant DNA technology in the laboratory.
The most common technique for producing insulin recombinant involves the insertion of human insulin genes into a bacterial or yeast host cell. Host cells are grown in large fermentation tanks and fed with a nutrient-rich solution so that they grow and produce large amounts of insulin.
The recombinant insulin is then purified through a series of filtration and chromatography processes to remove impurities and yield high-quality, high-purity insulin.
It is purification process it also includes testing and quality control to ensure the safety and efficacy of the insulin.
Once the recombinant insulin has been purified, it can be used to make different formulations of insulin, such as insulin rapid-acting, long-acting insulin, and mixed insulin.
These formulations are used in the treatment of diabetes to help control blood sugar levels in people with type 1 and type 2 diabetes.
How is insulin produced artificially?
This is the organ from cows and pigs that they used to make insulin. Photo: iStock
Insulin is produced from artificial form using recombinant DNA technology in the laboratory. The process generally involves the following steps:
Obtaining the insulin genes: Human genes encoding insulin are identified and obtained from a DNA source, such as human cells.
Insertion of genes into a host cell: Insulin genes are inserted into a host cell of bacteria or yeast that are used to produce large amounts of insulin.
Host cell culture: Host cells containing the insulin genes are grown in large fermentation tanks and fed with a nutrient-rich solution. The cells multiply and produce large amounts of insulin.
Insulin purification: Insulin is purified through a series of filtration and chromatography processes to remove impurities and obtain insulin of high purity and quality.
Insulin formulation: Once the insulin has been purified, it can be formulated into different types of insulin, such as rapid-acting insulin, long-acting insulin, and mixed insulin.
It is important to highlight that the insulin production artificial insulin is a highly regulated and controlled process, and undergoes rigorous quality and safety controls to ensure that the insulin is safe and effective for use in the treatment of diabetes.
Where do you get insulin before?
This is the organ from cows and pigs that they used to make insulin. Photo: iStock
Before the production of artificial insulin using recombinant technology, insulin was obtained from the animal pancreasespecially of pigs and cows.
In 1922, Frederick Banting y Charles Best they discovered insulin and began to produce insulin from the pancreases of animals. Insulin was extracted from the pancreases of euthanized animals, purified, and formulated for use in the treatment of diabetes.
However, animal insulin had some limitations, such as the possibility of causing a allergic reaction in some patients and variability in the potency and duration of insulin action. Furthermore, the supply of animal insulin was not sufficient to meet the increasing demand for insulin for the treatment of diabetes.
With the introduction of recombinant DNA technology in the 1980s, it was possible to produce artificial insulin more efficiently and with greater purity and uniformity compared to animal insulin. Since then, recombinant insulin has become the main source of insulin for the treatment of diabetes.
You may also like: What is necrotizing fasciitis
Have you ever imagined that the insulin that your ancestors possibly used was obtained from the pancreas of pigs and cows?