Do you suffer from chronic fatigue? Unfortunately, finding the source of this problem can be extremely difficult, as there are many conditions that can cause it to fail. we feel constantly tired.
For example, two studies have found that chronic fatigue could be a symptom of a problem with microbiota intestinalthe set of bacteria that naturally inhabits our digestive tract and has a determining influence on many aspects of our health.
Lower microbiome diversity
The works, financed by the National Institutes of Health (NIH) – of the United States and published in the specialized media Cell Host & Microbeare based on the comparison of the microbiological analysis of intestinal samples taken from patients with chronic fatigue or myalgic encephalomyelitis and that of samples taken from healthy patients.
More specifically, one of them used samples from 106 people with the condition and 91 healthy controls; the second, of 149 patients with the condition and 79 healthy controls.
Analyzes of different types, which included follow-ups over time, in a simplified way, showed that many of the people with chronic fatigue had abnormally low levels of ccertain bacterial species compared to healthy controls; Several of these species are considered to have salutary effects on people’s health.
chemical imbalances
For example, species like Faecalibacterium prausnitzii y Eubacterium rectale produce a metabolite (a product of their own chemical processes) called butiratowhich is an important source of energy for the cells that line the interior of the digestive tract.
In contrast, people with chronic fatigue tended to report abnormally high levels of other species as Enterocloster bolteae o Ruminococcus gnavuswhich have been associated with autoimmune diseases and irritable bowel syndrome.
These conclusions represent important and valuable knowledge, not only because of their implications on the pathology of the disease, but also because they can serve as a basis for considering new biomarkers for a more accurate diagnosis of patients with the condition.
References
Guo et al. Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS. Cell Host & Microbe (2023) DOI: 10.1016/j.chom.2023.01.004
Xiong et al. Multi-‘omics of host-microbiome interactions in short- and long-term Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Cell Host & Microbe, February 8, 2023. DOI: 10.1016/j.chom.2023.01.001