2023-07-27 16:57:32
The question of whether young blood or old blood controls longevity is the subject of debate among the scientific community. Is there any compound in young blood that can rejuvenate old blood cells?
A study published today in the journal «Nature Aging» brings new data to this controversial issue by revealing that a surgical process of joining the circulatory systems of a young and old mousecalled parabiosis heterochronic, can slow aging at the cellular level and extend the lifespan of the oldest animal by up to 10%.
The team of Duke Medical Center (USA) found that the anti-aging benefits lasted longer the longer the period the animals shared circulation, even after they were no longer connected.
These findings suggest that animals young people have components and chemicals in their blood that contribute to vitalitywhich could be isolated as potential therapies to speed healing, rejuvenate the body, and add years to the lives of older people.
The process represents the first evidence that aging can be slowed downwhich translates into an extension of useful life and health, according to the study’s lead author, James White.
The study focused on determining whether the benefits of heterochronic parabiosis, which involves the surgical fusion of two animals of different ages to share a circulatory system, were fleeting or longer lasting.
Previous studies had documented anti aging benefits in tissues and cells from older mice after three weeks of parabiosis, but this team wondered if those effects would persist over a longer period, in this case, 12 weeks.
The experiment involved four-month-old mice and mice older than two years. Following a two-month follow-up after separation, the older mice exhibited and lived 10% longer than animals that had not undergone the parabiosis procedure.
At the cellular level, parabiosis significantly reduced the epigenetic age from blood and liver tissue, and showed changes in gene expression that opposed aging but were similar to life-prolonging interventions such as caloric restriction.
Surprisingly, the rejuvenation effect was maintained even after two months of separation from the mice.
White points out that while this type of research is neither practical nor ethical in humans, it opens the door to exploring factors in young blood that cause this antiaging effect. Whether proteins, metabolites, or new cells are driving this phenomenon remains to be determined.
The finding suggests possible future therapies based on the findings in young blood to treat aging and improve health in older people.
In summary, the study showed that heterochronous parabiosis may have beneficial effects in slowing aging and prolonging life in older mice, suggesting possible future therapies based on the findings in young blood to treat aging and improve health. in older people.
However, the results of this work contrast with those of another published in «Rejuvenation Research» in young and old mice surgically joined to share blood circulation for three months did not benefit significantly in terms of lifespan.
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