2023-09-26 11:04:00
As we age, it is common for humans to experience problems associated with cognitive decline and memory. Studies to slow down this process have grown. Japanese research has shown that a compound present in coffee beans can improve learning levels and even be a solution for this.
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Positive effects of coffee
Positive effects of coffee components are already known. Now, a study from the University of Tsukuba, in Japan, has looked into how trigonelline (or TG), a compound present in high concentrations in coffee beans and proven to be beneficial to the nervous, digestive and skin systems, affected the functioning of cognitive function of rats. The conclusion is that the substance has therapeutic effects.
For now, the study has been limited to tests on rats (Image: shutterstock/Egoreichenkov Evgenii)
Testes
To reach this conclusion, the researchers used “elderly” mice that already had learning deficits and memory loss, a common symptom of cognitive decline in animals (and humans) of advanced age. They then administered 5 mg of TG per day for 30 days. After this time, the rats underwent a behavioral test to measure learning and memory. Scientists noticed that the rats that received TG showed an improvement in these aspects compared to rats that had the same symptoms, but did not receive the component. With this answer, they began to study the effect of TG on the hippocampus, part of the brain associated with learning and memory. (Image: shutterstock/Farknot Architect)
New discoveries
They discovered that the mice underwent a modulation in the organ’s cells, improving their performance in relation to cellular energy production, inflammation and autophagy (the ability to reuse “old” cells). This, consequently, improves the functioning of the organ and the capacity of the neurons responsible for learning and memory retention.
Thus, they elevate neural performance and slow cognitive decline.
According to the researchers, who spoke to the website New Atlasthe newly discovered properties of TG can be used, for example, as a medicinal compound combined with the treatment of cognitive decline.
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