2023-11-06 15:32:00
Scientists have made a significant breakthrough in the fight against dementia with the use of medication. A new study published in the journal JAMA Network Open has shown that certain diabetes medications, specifically metformin hydrochloride, may have a positive effect on the brain and lower the risk of developing dementia.
Dementia is a major medical and social challenge, with approximately 1.8 million people affected in Germany alone. Researchers from Boston University and California have provided hope for those affected and their families with their findings.
The study evaluated the medical records of 29,000 patients who were using metformin hydrochloride to treat their type II diabetes. Out of this group, 12,220 patients had to switch to other medications due to kidney damage or side effects. The occurrence of dementia was found to be much higher in patients who stopped using metformin. In comparison, the group that continued taking the medication had a 21 percent lower risk of developing dementia.
Originally developed to treat diabetes, metformin hydrochloride has shown additional effects in reducing glucose production in the liver, decreasing cellular energy requirements, and inhibiting inflammation. It has also been shown to slow the growth of certain prostate cancers in previous studies.
Scientists believe that the anti-dementia effect of metformin is due to its anti-inflammatory properties. Inflammation in the brain is a significant factor in the development of dementia.
While age and genetics are the most significant risk factors for dementia, researchers at the German Center for Neurodegenerative Diseases (DZNE) have found that lifestyle factors can also play a role in prevention. They identified eleven lifestyle factors that contribute to 38 percent of all dementia cases. Low education, smoking, and poor hearing were identified as the top three culprits.
It is important to note that healthy individuals should not take metformin as a precautionary measure. Another study has shown that the medication can negate the positive effects of exercise.
With this breakthrough, there is newfound hope in the fight against dementia. Further research and clinical trials are needed to fully understand the potential impact of metformin hydrochloride and other similar medications on dementia prevention and treatment.]
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