National Institute of Nuclear Technology Receives National Research Award for Cancer Therapy Invention

2024-02-06 08:41:00

Researchers from the National Institute of Nuclear Technology (Public Organization) led by Dr. Sakchai Laksi, head of the inventor team attended an audience to receive a certificate of honor from the National Research Award Invention Award Fiscal year 2024, very good award from the work titled “OhGold4Life: Smart nanocarriers as an emerging platform technology of multifunctional gold nanohybrids for effective cancer therapy), which is an emerging technology platform of nanohybrids. Gold by working in many functions It is a smart nanocarrier for efficient anticancer drug delivery system.

Assoc. Prof. Dr. Thawatchai Onchan, Director of the National Institute of Nuclear Technology (Public Organization) revealed that the research team of the National Institute of Nuclear Technology (Public Organization) or NSTDA has submitted an invention to participate in the 2024 National Research Award competition organized by the National Research Council of Thailand. It is the result of an invention by a team of DST researchers, with Dr. Sakchai Laksi, the head of the inventor team. Along with the team consisting of Dr. Thitirat Rattanawongwiboon, Miss Pattra Lertsarawut, Dr. Kesinee Hemwichian, Dr. Thanakorn Sangthaweesin and Dr. Teeranant Taengthong, named “Oh Gold for Life ” (OhGold4Life: Smart nanocarriers as an emerging platform technology of multifunctional gold nanohybrids for effective cancer therapy), which is a platform for the delivery system of anticancer drugs synthesized from nuclear technology. It is a simple and environmentally friendly process. This work was honored with a National Research Award. Invention Award Fiscal year 2024 and previously OhGold4Life received the Silver Medal of the International Innovation Award 2023 from the Malaysia Technology Expo 2023, which is one of the prides of TST for demonstrating the benefits of using nuclear technology in Caring for and maintaining the health of Thai people

Dr. Sakchai Laksi, OhGold4Life project leader, said cancer is one of the leading causes of death among many people around the world. Chemotherapy is one of the most popular cancer treatments with the use of anticancer drugs (Anticancer Drugs (ACDs)) to help in treatment. However, this method was found to have limitations due to its high toxicity to normal tissues. Causes extremely unwanted side effects Therefore, many researchers are trying to solve this problem by delivering anticancer drugs using nanometer drug delivery systems. Which is the one that stands out very much. Gold nanohybrids (AuNHs) lead to this invention, which is the development of smart nanocarriers as an emerging technology platform of gold nanohybrids (OhGold4Life or Oh Gold Foam). OhGold4Life is a multi-functional anticancer drug delivery system platform synthesized using nuclear technology in a simple and environmentally friendly process. The particles are functionally modified with biopolymer derivatives in a systematic interaction that promotes OhGold4Life’s specificity against cancer cells. Increase the efficiency of anti-cancer drugs and reduce side effects in use From the results of the experiment, it was found that OhGold4Life was able to deliver the anticancer drug Camptothecin (CPT) and increased its ability to inhibit human lung cancer cells 2.82 times higher than CPT alone. At the same time, it was only toxic to normal human lung cells. only a little This drug delivery system also shows specific cell entry through folate receptor-mediated endocytosis and has high anticancer activity. Stimulates cancer cell death systematically by increasing cancer cell apoptosis by 13.97% and helps stop the growth of cancer cells in the G0-G1 phase of the cell cycle. According to these experimental results, Therefore, it is shown that the delivery of anticancer drugs using OhGold4Life as one of this emerging platform technologies. It is a technology with potential that should be continuously developed as an effective anti-cancer drug delivery system. Helps treat and cure cancer This gives cancer patients more treatment options and also helps improve the quality of life of cancer patients.