2024-02-09 11:31:00
That ours Nutrition Many people already know that it can have a major impact on our health. A varied and wholesome diet, as recommended by the German Nutrition Society, is considered preventative and health-promoting, especially with regard to the diseases of modern civilization. According to the Nutri-Epigenetics has an influence on our genetic makeup and can therefore Health influence several generations.
Nutri-epigenetics: How nutrients reprogram our genes
Every cell in the human body contains a cell nucleus in which the individual heritage is present. The chromosomes, which carry the genes, are made of chromatin. When these chromatins change permanently, Epigenetics spoken. As a result of these changes, a genome can produce a large number of different variants. However, the maintenance and formation of epigenomes is essential for reproduction as well as for cell type identity and cell differentiation. In addition to DNA mutation, in which the genetic material is permanently changed due to incorrect sequencing, epigenetic dysregulation can play a decisive role in the course of Diseases such as cancer, metabolic diseases and neurodegenerative diseases.
Die Nutri-Epigenetics is a branch of epigenetics and deals with the connection between nutrients and dietary patterns and the epigenetic modifications that may result from this. The research begins during embryonic development in the uterus. The diet of the person giving birth and thus the fetus already has development-specific consequences. Epigenetic changes are not rigid, they are changeable, unlike DNA mutations. According to nutri-epigenetics, micro- and macronutrients can lead to epigenetic modifications throughout life and thus influence physiological and pathophysiological processes.
The previous research results Nutri-epigenetics show that one balanced and varied diet crucial to maintaining the Health contributes and prevents diseases. The interactions of nutrients and their influences on the genome are very complex and the research potential is high. However, it is certain that epigenetic modifications can also occur in germ cells and thus passed on become. The lifestyle and nutritional style of the parent generation therefore has consequences for their offspring. According to Nutri-epigenetics, the way we eat can be influenced by the Health of our children and grandchildren decide.
Nutrition during pregnancy
A connection of Overweight and epigenetic changes have already been well researched. There is a direct connection between obesity and gestational diabetes in the person giving birth and the risk of birth complications and a possible metabolic disorder in the child. If a child is overweight at birth, the risk of becoming overweight over the course of their life is twice as high. This tendency to be overweight is the result of epigenetic incorrect programming.
According to the German Medical Journal, the existing research results can be broken down into three important points.
The importance of folic acid
The interaction between nutrients and DNA has its origins in a central process in the human body: C1 metabolism. Research has so far assigned a central role to two compounds within metabolism: S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH). All foods that have an effect on these two compounds contain substances containing methyl groups and can have a significant effect on epigenetics.
So far it has been determined that Folic acid or foods rich in folate for example, have a preventive property against colon cancer. Folate compounds are natural compounds found in foods. Foods containing folate include asparagus, cabbage, spinach, whole grain products, wheat bran, peanuts and walnuts, egg yolks and liver. The German Nutrition Society (DEG) recommends 300 µg per day for adults. For example, 100 grams of chickpeas contain 340 µg folate and 100 grams of broccoli contain 114 µg folate. Folate is a water-soluble vitamin required for DNA synthesis. In addition to the natural folate compounds, there are also synthetically produced compounds – these are called Folic acid. Too high a concentration of folic acid can Formation of tumors favor. One Overdose can occur due to increased intake of foods or vitamin supplements fortified with folic acid and is harmful. However, according to the DGE, based on current knowledge, an overdose of folate from natural foods is not possible.
In addition, nutrients such as vitamin B12, betaine, methionine and choline are believed to have an influence on C1 metabolism because they are rich in methyl groups. These include animal products as well as grain products, potatoes, lentils, beans, peas, nuts, soy flour, brewer’s yeast, beet plants, wheat bran and wheat germ. Most Studies Nutri-epigenetics have so far come from in-vitro or animal studies and can therefore be compared only partially transferred to humans.
Conclusion: research with potential
Nutri-epigenetics researches the connection between nutrients and diets and their effects on epigenetic changes in the human genome. There is evidence that diet and lifestyle are not only important for one’s own health, but also for the health of future generations. In order to better understand the mechanisms, importance and influence of nutrition, further research in this area is necessary.
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