2024-02-16 16:54:00
A group of scientists investigated the relationship between periodontitis and diabetes and used single-cell RNA sequencing to explore the systemic immunological connections between periodontitis and diabetes.
They were able to identify an increase in proinflammatory cytokines in classical monocytes in both the classical periodontitis group and the periodontitis with type 2 diabetes (PDDM) group.
The study highlighted the enhanced Resistin pathway in both groups, suggesting a shared intercellular pathway that contributes to the complex periodontitis-diabetes mellitus relationship.
The research provided a unique immunological explanation for the association between type 2 diabetes and periodontitis. Uncovering changes at the level of immune cells offers a new perspective on the systemic impact of these prevalent health conditions. The findings advance scientific understanding and lay the foundation for potential interventions to reduce the risk and impact of diabetes in people with periodontitis.
This groundbreaking study was conducted by researchers from the Republic of Korea led by Assistant Professor Yun Hak Kim of Pusan National University and was published in the journal Clinical and
Translational Medicine .
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