Superficial wounds on the skin can cause changes in the intestine – Olhar Digital

2024-04-24 20:26:28

Experiments conducted by a team of dermatologists from the University of California in San Diego, in the United States, showed that superficial damage to the skin is capable of causing changes in intestinal bacteria, unbalancing their defenses and altering the composition of the intestinal microbiome. The study was published in the journal Nature Communications.

Understand:

• Dermatologists have discovered that superficial damage to the skin can cause intestinal changes;
• The team made 1.5 cm incisions in the skin of mice and then compared the animals’ feces with those from another group of guinea pigs;
• It was observed that injured rats had more disease-causing bacteria than beneficial ones;
• Another group received fecal transplants from the injured mice, and doctors saw that disease susceptibility was transferred along with the gut microbiome;
• Human research must be done to confirm the discovery;
• The study was published in the journal Nature Communications.

(Imagem: Shutterstock/DudnikPhoto)

In addition to organs that come into direct contact with the “outside” world, other organs – such as the intestine and lungs – also have barriers to define and protect the body’s borders, preventing the excessive growth of microbes – whether beneficial or unwanted intruders. , such as blood worms and fungi.

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Studies point to a link between skin wounds and intestinal disorders

During experiments to prove the hypothesis, the team made 1.5 cm incisions in the skin of mice. They then compared the guinea pigs’ feces with those of another group of mice to analyze their gut microbiomes. The scientists observed that the injured mice had more disease-causing bacteria and fewer beneficial bacteria – signs that the microflora had undergone significant changes.

(Imagem: New Africa / Shutterstock)

Later, other mice received fecal transplants from guinea pigs with skin wounds that had developed colitis. The team observed that disease susceptibility was transferred along with the gut microbiome.

“Previous studies have observed dysbiosis in the gut microbiome of individuals with inflammatory dermatological diseases; it was assumed that microbes in the gut influence the skin,” the dermatologists wrote in the study. Human research must be carried out to confirm the discovery, which, as the team highlights, “provides an unexpected explanation for the association between skin and intestinal diseases in humans”.