2024-05-26 05:49:34
(ANSA) – NAPLES, MAY 23 – A examine solely by the Pascale Tumor Institute of Naples, accepted by the journal ‘Frontiers in Immunology’, has demonstrated, for the primary time, that Sars-Cov-2 has molecules (antigens) just like cancerous ones.
Vaccinated topics or those that have contracted the Coronavirus an infection present a cross-immune response. Consequently, publicity to virus antigens may signify a “preventive vaccination” for cancers particularly of the breast, liver, colon and melanoma.
The work, we learn in a notice from Pascale, accepted for publication (first names co-authors Concetta Ragone and Angela Mauriello, final names co-authors, Mariella Tagliamonte and Luigi Buonaguro) describes for the primary time that the Sars-CoV virus -2 presents in its proteins fragments (antigens) that share a excessive homology of sequences and conformation with antigens expressed by tumor cells. Particularly, these tumor antigens are particularly expressed by breast, liver, colon and melanoma tumor cells.
Moreover, it has been demonstrated that cells of the immune system (T lymphocytes), from vaccinated topics or those that have contracted the Sars-CoV-2 an infection, are in a position to cross-react with viral and tumor antigens. This phenomenon, outlined as “molecular mimicry”, means that the immunological response induced by viral antigens and, consequently, the immune reminiscence that has been established, could signify safety towards the event of a tumor.
“This end result, additionally obtained with the help of the Scientific Pathology Laboratory Unit of the Pascale Institute, directed by Ernesta Cavalcanti – says Luigi Buonaguro, director of the Laboratory of Progressive Immunological Fashions, coordinator of the examine – has a possible influence of appreciable relevance medically globally. Beforehand, anecdotal instances of tumor regression have been reported in topics affected by Covid-19, together with in our Institute. That is the primary time that the mechanism by which this phenomenon happens is demonstrated to the appreciable expertise acquired by our analysis group within the particular sector of molecular mimicry, it’s the first time that not solely are the similarities between the molecules of the Sars-CoV-2 virus and tumor molecules described intimately but in addition the capability of the cells of the immune system to cross-react with such molecules”.
It is going to be the epidemiological knowledge of the longer term months-years that can verify or not the true influence of this molecular mimicry on the incidence (variety of new instances) of breast, liver, colon and melanoma tumors. In the meantime, the scientific director of the Neapolitan Irccs, Alfredo Budillon, defines it as “a examine of nice curiosity”, confirming, as already demonstrated in different publications by Luigi Buonaguro’s group, “molecular mimicry may be exploited for the design of personalised therapeutic anti-tumor vaccines which we have now been engaged on on the Institute for a while.” “I’m extraordinarily proud – underlines the final director of Pascale, Attilio Bianchi – of this end result, the results of a challenge designed and performed solely inside our Institute, which may have a potential influence of extraordinary magnitude on the well being of the world inhabitants”. (HANDLE).
2024-05-26 05:49:34