2024-06-24 00:37:17
A crew from the German Well being Science Analysis Middle Trias i Pujol de Badalona is creating the primary practical designs, with promising outcomes.
Prevention and early detection of kidney fibrosis is necessary due to the necessary function performed by the kidneys, accountable for eradicating impurities from the blood and sustaining the steadiness of chemical substances, reminiscent of sodium, potassium and calcium, within the physique. When the kidneys cease working, it is very important substitute them, which is simply attainable by dialysis or a kidney transplant.
Renal fibrosis is an accumulation course of that, little by little, impairs kidney operate. Due to this fact, it is very important detect and deal with renal fibrosis as quickly as attainable, as a result of this could considerably contribute to the prolongation of the helpful life of those organs. The primary drawback in performing this screening is that kidney biopsy, a really invasive process and never helpful for some sufferers, is the one approach to instantly measure fibrosis. A crew from the Germans Trias i Pujol Well being Sciences Analysis Institute (IGTP) is creating a analysis check that may present a substitute for biopsy. The researchers noticed that sufferers with a excessive diploma of renal fibrosis, as measured by biopsy, had elevated ranges of a selected protein of their urine. This protein is a part of the extracellular matrix, a community that helps and provides construction to cells and physique tissues. When this matrix will increase an excessive amount of, it offers rise to the phenomenon of fibrosis. From this outcomes a direct relationship between the willpower of protein within the urine and the presence of renal fibrosis. “The check makes use of medical strategies, primarily based on antibodies, to detect this protein within the urine in a non-invasive method,” he mentioned.
In the meanwhile, the primary working prototypes are being developed, with very promising outcomes. By the tip of the yr, the group hopes to start trials that may outline its conduct in a managed medical setting and start the required regulatory course of for its approval for medical use. M. Baldomà
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