2024-06-28 18:52:56
(ANSA) – TRENTO, JUNE 28 – Terra is the identify of a particular RNA molecule that, within the advanced mechanism of mobile functioning, appears to play a key function within the onset of some tumors. The demonstration comes from a gaggle of ten researchers from the Division of Mobile, Computational and Built-in Biology (Cibio) of the College of Trento, in collaboration with two colleagues from the College of Montreal. The analysis was led by Emilio Cusanelli, head of the Laboratory of Mobile Biology and Molecular Genetics of the Cibio Division. Terra is an acronym that stands for “Telomeric repeat-containing RNA”. The molecule is in actual fact generated by telomeres, the ends of chromosomes, composed of DNA sequences repeated many occasions. The existence of Terra was already identified, as had been its important features for the soundness of telomeres. The novelty that the analysis group found is the regulatory exercise, by Terra, of a selected enzyme, known as telomerase, in people.
“What we noticed – explains Cusanelli – is that Terra, when it localizes on the ends of chromosomes, is ready to forestall the interplay of telomerase with telomeres.
It thus acts as an inhibitor of the enzyme, stopping the lengthening of telomeres. The research of the mechanisms that act in regulating the localization of Terra molecules might due to this fact result in the identification of recent therapeutic targets for the remedy of tumors.”
To reach on the revealed outcomes, the investigation was carried out within the laboratory, with human tumor cells in tradition, because of a sequence of microscopy methods, molecular biology approaches and molecular genetics. These methods have allowed us to review Terra additionally in residing cells, saved in tradition in secure and monitored environmental circumstances.
To hold out these research, a collaboration can also be underway with the Santa Chiara hospital in Trento, particularly with the operational models of Pathological Anatomy, Medical Oncology, Surgical procedure and Neurosurgery, and the contribution of Airc. The target is to analyze the potential for finding out Terra as a molecule of diagnostic and prognostic significance for tumors. (HANDLE).
2024-06-28 18:52:56