Seemingly harmless bacteria cause 500,000 deaths a year, study says

2024-07-10 10:56:10

A bacteria apparently harmless causes half a million deaths a year, according to a study published in the journal Science. Researchers have mapped the genome of Bacterial species ‘Pseudmonas aeruginosa’which becomes a harmless bacteria cause 500,000 deaths a year. Scientists, according to the study, have discovered that these organs take advantage of the immune defect in patients with cystic fibrosis to survive and continue on their own.

“Pseudomonas aeruginosa causes very serious infections, especially in people with underlying immune systems or lung diseases such as cystic fibrosis (CF). However, it is unclear how Pseudomonas aeruginosa has evolved to become highly pathogenic the most consistent and distributed throughout the world text published in a scientific journal.

Andres Flotoprofessor of Respiratory Biology at the University of Cambridge and author of the study, pointed out that “In the last 200 years, certain bacteria, called clones, managed to absorb new genes and become more capable of human disease.” These clones then expanded and spread around the world. The most likely expansion date for the first clone is around 1890, although the confidence interval is wide.”

500,000 deaths per year

Researchers have discovered that about 21 of those “epidemic twins” They are responsible for more than 50% of all Pseudmonas aeruginosa infections worldwide. It is widespread in natural and artificial environments and has become an increasingly important human opportunistic pathogen, causing severe nosocomial lung, soft tissue and systemic infections, as well as chronic lung infections in individuals. with inflammatory lung diseases.

Diseases that cause increased morbidity and mortality. “Antimicrobial resistance in P. aeruginosa is increasing worldwide, as evidenced by its inclusion in the World Health Organization’s ESKAPE list of pathogens, and it is responsible for more than 500,000 deaths a year“.

After checking about 10,000 human, animal and environmental samples of this microorganism, the Cambridge researchers managed to trace the family history of ‘Pseudmonas aeruginosa’, although they also created a resistance mechanism that can be used to understand its resistance. In samples from patients with cystic fibrosis, researchers discovered that macrophages were unable to eliminate Pseudmonas aeruginosa: these clones managed to survive within macrophages and establish an infection.

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