2024-07-19 00:10:53
Singapore research team publishes international academic journal
Deletion of a gene that promotes inflammation
Improved immunity – Increased lifespan by 25%
When the expression of a specific protein that promotes inflammatory responses was suppressed, the health of old mice improved and their lifespan increased. Further studies are needed to confirm the effects on humans. However, it is noteworthy that new clues have been found through animal experiments that can improve health and lifespan due to aging.
A research team led by Professor Stuart Cook of the Duke University of Singapore announced the results of a study containing these contents in the international academic journal Nature on the 17th (local time).
Previous studies have shown that intracellular signaling pathways involved in health and longevity do not function as smoothly as we age, as pro-inflammatory signaling molecules associated with the inflammatory response disrupt the signaling pathways.
The research team focused on ‘interleukin 11 (IL11),’ a protein involved in pro-inflammatory signal transmission. Interleukin is a type of immune protein that interacts between white blood cells. Clinical trials are also underway to develop a treatment for pulmonary fibrosis, which causes scarring and stiffness in human lung tissue, using interleukin.
Results from experiments on mice showed that as mice aged, the amount of interleukin 11 produced in their bodies increased. As a result, various intracellular signaling pathways that affect the aging phenomenon were also rapidly activated.
By deleting the gene involved in the production of interleukin 11, the progression of physical changes due to aging was prevented. The decline in metabolic function was suppressed and the body’s defense function against various diseases was improved. In particular, the lifespan of both male and female mice was extended by 24.9%.
When antibodies, a glycoprotein that inactivates viruses and bacteria, were used to suppress the production of interleukin-11, metabolism and muscle function were also improved. In 75-week-old mice, which is equivalent to 55 years of human age, the lifespan of males and females increased by 22.4% and 25%, respectively. It was also shown to reduce the occurrence of age-related cancers.
“When combined, these results suggest that inhibiting interleukin-11 can improve the health and extend lifespan of aged animals,” the research team said. However, they added that further research is needed to confirm whether the same effect occurs in humans.
Park Jeong-yeon, Donga Science Reporter [email protected]
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2024-07-19 00:10:53