Aging is not a slow and steady process, reveals a study published in the journal “Nature Aging”.Two radical changes occur at the ages of 44 and 60, according to the scientists behind this study.These findings could explain why health issues, notably cardiovascular diseases, arise at certain ages.
Reaching 30 years old, then 40 and 50, often brings anxiety. However, it may be unnecessary to worry too much at that time, according to a study published in the journal Nature Aging, reported on Wednesday, August 14 by The Guardian. The scientists behind this study detected two major waves of age-related changes in humans: at 44 and then at 60 years old. In other words, the research suggests that rather than being a slow and steady process, aging occurs in at least two accelerated bursts.
The scientists, led by Professor Michael Snyder, director of the Stanford Center for Genomics and Personalized Medicine, followed 108 healthy volunteers aged 25 to 75, of which 51.9% were women. These volunteers provided blood and stool samples, as well as skin, mouth, and nasal swabs every three to six months over a period ranging from one to nearly seven years. The researchers evaluated 135,000 different molecules and microbes.
“Truly spectacular changes”
“We do not simply change gradually over time. There are truly spectacular changes,” responds Michael Snyder to The Guardian, referring to “a period of radical change” at both 44 and 60 years of age, “regardless of the class of molecules examined.”
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The peak of aging occurring in mid-forties demonstrated by this study is unexpected. Scientists initially thought it resulted from changes related to perimenopause in women, which skewed the results for the overall group. But the data from this study indicate that similar changes also occur in men in their mid-forties. “This suggests that even if menopause or perimenopause may contribute to the changes observed in women in their mid-forties, there are likely other more significant factors influencing these changes in both men and women,” comments Dr. Xiaotao Shen, the first author of the study, based at Nanyang Technological University in Singapore.
Skin aging at 44 as at 60
The two waves of aging observed do not concern the same elements. The one occurring at 44 years is related to molecules linked to cardiovascular diseases and the ability to metabolize caffeine, alcohol, and lipids. The one observed at 60 years is associated with molecules involved in immune regulation, carbohydrate metabolism, and kidney function. Molecules related to skin and muscle aging are involved in both waves of aging.
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The results highlighted in this study could thus explain why spikes related to certain health problems, notably musculoskeletal issues and cardiovascular diseases, occur at certain ages. Previous research suggested a later peak of aging could occur at the age of 78. The latest study published in Nature Aging could not confirm these data as the oldest participants were 75 years old.
JC
Shifting Paradigms in Aging Research and Health Management
The recent findings published in Nature Aging reveal significant bursts in aging at the ages of 44 and 60, challenging the long-held belief that aging is a slow and steady process. As researchers like Professor Michael Snyder and Dr. Xiaotao Shen delve deeper into human biological changes, the implications for health management and preventive care are profound.
Understanding the Aging Process
With a dramatic shift in health markers at pivotal ages, future studies may pivot towards personalized health strategies aimed at these critical junctures. As we become more aware that men and women alike experience similar aging patterns, healthcare practitioners may focus on targeted interventions that preemptively address diseases that are closely tied to these age milestones.
Impact on Health Policies
As scientific understanding of aging evolves, public health policies are likely to adapt as well. There may be initiatives focusing on lifestyle modifications before the ages of 44 and 60, highlighting the need for early detection and management of cardiovascular health and metabolic diseases. This could lead to enhanced societal awareness regarding the importance of proactive health screenings and lifestyle changes.
Technological Integration in Health Monitoring
The information gleaned from longitudinal studies, such as those tracking molecular changes in blood and other bodily samples, could catalyze advancements in wearable technology. Individuals may begin to rely on smart devices that monitor health changes in real-time, enabling timely interventions. This integration of technology is expected to empower patients with the knowledge to make informed health decisions as they navigate these crucial periods of change.
Holistic Approaches to Longevity
Future health strategies may also embrace holistic approaches that consider not just physical, but also mental and emotional wellbeing. With the potential for significant health challenges at 44 and 60, developing a comprehensive support system that includes mental health resources and community engagement could be essential in promoting longevity and quality of life.