The Korea Disease Control and Prevention Agency (Director Young-Mi Ji) and the National Institute of Health (Director Hyun-Young Park) announced research results showing that monitoring and managing blood sugar and blood pressure are important for preventing dementia.
Dementia is a disease in which pathological changes such as Alzheimer’s disease indicators (accumulation of beta-amyloid, tau protein, and atrophy of the hippocampus) and vascular dementia indicators (cerebral leukodegeneration) lead to cognitive decline, and diabetes and hypertension are generally known as representative risk factors for dementia.
Through this analysis of a cohort of elderly dementia patients, the National Institute of Health confirmed that blood sugar variability and blood pressure variability affect Alzheimer’s disease indicators and vascular dementia indicators.
This study investigated normal and mild cognitive impairment subjects, not dementia patients, and found that as blood sugar variability increased, more severe white matter degeneration occurred and amyloid protein accumulation increased.
In addition, it was shown that the greater the variability of blood pressure (systolic and diastolic), the greater the accumulation of tau, and the greater the variability of diastolic blood pressure, the more severe the atrophy of the hippocampus. Thus, not only the levels of blood sugar and blood pressure, but also their variability can affect the worsening of the disease, so management is important.
Professor Sang-Won Seo, who led the research, said, “This study shows that blood sugar and blood pressure management are important for effective dementia prevention. It will be necessary to prevent cognitive decline by properly managing blood sugar and blood pressure levels as well as ensuring that changes in blood sugar and blood pressure do not become large.”
Park Hyun-young, director of the National Institute of Health, said, “In preparation for the era of a super-aging society, dementia prevention is important from a public health perspective,” and “The National Institute of Health will continue to support dementia prevention research in the future.”
Reporter Song Chi-hoon, Donga.com [email protected]
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2024-09-23 13:02:50