Medical Genome Center It states that there is an urgent report from “Belgium” that there has been an outbreak of Omikron. Subspecies BA.1, BA.1.1, and BA.2 have been concomitantly since Dec. 64, which is likely the reason for the continuous detection of invasive hybrids since Feb. 13. .65
Medical Genome Center Downloaded the entire genome of a Belgian crossbreed. From the global COVID-19 database “GISAID”, 22 samples were analyzed. found that the genetic code is similar to the omichron The strain could not be identified or identified with “Pangolin Application (Pango v.3.1.20 2022- 02-28)”, but an in-depth analysis with “Nextclade Application” showed that the virus in the cluster Most of the genome was derived from the “BA.2” omicron subspecies, but a minority was derived from the “ORF1a (2832-10029)” and “ORF1b(160464-18163)” genes of the omikron line. The BA.1.1 subspecies were interbred to form a BA.2/BA.1.1 recombined linage, causing a leaping mutation.
Originally, BA.2 had 10 different mutations from BA.1 and BA.1 had 13 different mutations from BA.2. The Wuhan primitive strain reaches 100 positions, and unlike BA.2 by approximately 30 positions, this is probably the strain with the most mutations at the moment.
Based on calculations from the genetic code and detection intervals. It was found that the BA.2/BA.1.1 recombined linage had a “growth advantage” or the ability to spread about 0.47 times higher than that of BA.2 (47%), which was not much.
There are no epidemiological data on how many percent more quickly the BA.2/BA.1.1 recombined linage is transmitted than BA.2. And there is no clinical data whether infected with BA.2/BA.1.1 recombined linage strains are more or less severe than omicron strains BA.1, BA.1.1, BA.2.
Immune evasion or vaccine inefficiency is not likely to differ from BA.2 because many mutations were not found on the genome for the “S gene” that controls thorn formation.
From scanning in the global coronavirus database “GISAID”, which is now gradually collecting the genetic code for the entire genome of the coronavirus 2019 from the start of the outbreak to the present, more than 9.63 million samples have not found BA.2/BA. 1.1 recombined linage in Thailand
In the near future, if there is a need to screen for a large number of “BA.2 + BA.1.1” hybrids, the Medical Genome Center can develop a “Mass Array Genotyping” test kit to test the genetic code of the hybrids. Fast in 24-48 hours with shorter time and less cost than whole genome transcription. It takes no more than 2 weeks to develop the test.