Medical Genome Center releases data on 8 coronavirus hybrid strains Which species should be the most careful and concerned?
Today (28 March 65) Facebook, the Center for Medical Genomics posted a message saying: Which of the “eight” hybrids of the coronavirus 2019 should be the most careful and concerned? with “Five” answers that will help the people. Better understanding of “Covid-19 hybrid species”
Q1: How does the “Corona virus 2019” hybrid occur?
A1: When viruses of similar species “Two strains”, such as delta and omikron, or omikron subspecies BA.1 and BA.2, multiply in the same cell. Coinfection The activity that the virus performs immediately upon entering a cell is to maximize the number of offspring.
The viral enzyme responsible for generating new genomes using the genome of the first species (template) went on for some time and failed to create a new genome, that is, the enzyme jumped. The second species’ genome was then used as a prototype for genome-building (template switching) to be completed. Resulting in a virus (genome) hybrid between the two species (Figure 1).
Q2: Why are so many hybrid species discovered during this period?
A2: The reason why so many hybrids have been reported from around the world at this time is because we have recently had a large genomic heterogeneity virus spreading all over the world, such as the germ line. “Delta”, BA.1 and BA.2 – when these viral hybrids occur. We can easily screen these hybrids through bioinformatics. Bioinformatic, even though the genome’s transverse portion is small (Figure 2).
Another reason is that an outbreak of BA.1 was followed by BA.2 (in Europe and the US) while also having a very high delta outbreak – opening the possibility of co-infection. (coinfection) resulting in hybrid species
Q3: The 2019 coronavirus is a hybrid species. How many species are there?
A3: Coronavirus 2019 strain determination is based on the COVID-19 strain code. The entire genome was submitted into the online program “Pangolin COVID-19 Lineage Assigner,” “PANGOLIN; Phylogenetic Assignment of Named Global Outbreak LINEages (https://pangolin.cog-uk.io/).
PANGOLIN divides the hybrids into 2 categories of 8 species.
Category 1 Hybrids between “Delta x BA.1” consist of 2 members.
XD- is a cross between the Delta x BA.1 lineage found in France and contains the S gene that produces spikes. The other part is the genome from the delta.
The XF-genome is a mixture of S gene and key protein particle protein gene, derived from BA.1 and part 5′ from the delta genome.
Category 2 Hybrids between BA.1XBA.2 consist of 6 members.
XE-found in England The genome is a mixture of S gene and key protein particle protein gene from BA.2 and part 5 from the genome of BA.1, showing a growth advantage over BA.2.
XG-found in Denmark
XH-found in Denmark
XJ-found in Finland
XK-found in Belgium There are nearly 100 different mutations from the original Wuhan virus, more than any other strain. not found in Thailand
XL-found in England
XG,XH,XJ,XK, and XL hybrids have a genomic break point between BA.1 and BA.2 in the ORF1ab gene region.
(Picture 3)
Q4: Which hybrid coronavirus 2019 strains are of concern and should be monitored?
A4: XD hybrids should be closely monitored. This species is found in France, Germany, the Netherlands and Denmark. The genome controlling the formation of “thorns” comes from the omikron (BA.1) and most of the rest of the genome belongs to the delta. If inbreeding Recombination could theoretically cause a “super bug” or a highly contagious strain. and causing more severe disease than any species we’ve ever known But real world data has yet to find that XD is spreading rapidly and causing severe COVID-19. However, as a precaution, it should be closely monitored. which the Medical Genome Center It is an important duty that must be performed continuously.
The case of crossbreeds XF, XE, XG,XH,XJ,XK, and XL in the issue of immune evasion. the ability to spread Based on the genetic code on the genome, many experts agree that it is unlikely to be any different from Omikron (BA.1 and BA). .2)
However, the “XK strain” found in Belgium showed nearly 100 different mutations from the original “Wuhan” virus, more than any strain. should be careful as well Clinical data are not yet available. and still not found in Thailand
Q5: How do we know the types of hybrids for what purpose?
A5: The emergence of hybrid species poses a risk of leapfrog mutation. which may affect the control of the outbreak Potentially Invalid ATK PCR Screening Vaccine protection that may be less effective and ineffective antiviral and synthetic antibody therapy.
We therefore need to know that we are fighting the COVID-19 virus. Which species mutated in detail
“Know him, know us, a hundred battles, a hundred wins.”
(Adapted from Sun Tzu’s Book of Dossier)
“He” in this case means “Coronavirus 2019”.
“We” means the World Health Organization and all countries around the world who have joined hands to control, prevent and treat COVID-19.
Sun Tzu’s book of Dossier wrote:
“If you know him, know us, even if you fight a hundred battles, there is no danger.
If you don’t know him, but only know us Win or lose will be matched.
If we don’t know about him, we lose ourselves. must be defeated every time there is such a strategy.”
Coronavirus disease 2019 strain testing at a medical genome center This 24-48 hour action is to encourage the treating physician to choose the correct antiviral and synthetic antibody drug for the most vulnerable infected with the strain. and in time to give drugs and synthetic antibodies within 3 days of infection.
https://assets.publishing.service.gov.uk/…/Tech…
https://twitter.com/PeacockFlu/status/1504158873938272269…
Information from the Medical Genome Center.
picture from Reuters