Changes in the gut microbiome are observed in patients with cutaneous T-cell lymphoma (CTCL) compared to healthy controls. These changes are more pronounced in patients with advanced CTCL. The taxonomic shifts associated with CTCL are similar to those previously reported in atopic eczema and opposite to those in psoriasis, indicating microbial parallels and skin barrier differences between these conditions.
The purpose of this case-control study conducted between January 2019 and November 2020 at Northwestern University’s multidisciplinary CTCL clinic was to examine the gut microbiome in patients with CTCL relative to healthy controls. In addition, 16S rRNA sequencing and bioinformatics analyzes were used to characterize the microbiome in fecal samples from 38 patients and 13 age-matched healthy controls from the same geographic region.
A trend for lower microbial α-diversity was seen in patients with CTCL and was significantly lower in patients with advanced CTCL compared to controls (p = 0.015). No differences in β diversity were found. Specific taxa were significantly reduced in patient samples; significance was determined using adjusted p-values (q-values) calculated with the Benjamini–Hochberg false discovery rate (FDR) correction. Significantly reduced taxa in patient samples included the strain Actinobacteria (q = 0.0002), classes Coriobacteriia (q = 0.002) and Actinobacteria (q = 0.03), order Coriobacteria (q = 0.003) and genus Anaerotruncus (q = 0.01). of families Eggerthellaceae (q = 0.0007) in Lactobacillaceae (q = 0.02) were significantly reduced in patients with a high degree of skin disease.
Bron:
Hooper MJ, LeWitt TM, Pang Y, et al. Gut dysbiosis in cutaneous T-cell lymphoma is characterized by shifts in relative abundances of specific bacterial taxa and decreased diversity in more advanced disease. J Eur Acad Dermatol Venereol. 2022 Apr 2. Online ahead of print.