Combined drugs to treat coviral-19. Open the criteria. Solve the doubts why each person receives differently: PPTVHD36

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Amid the COVID-19 outbreak That is unlikely to end easily after new mutations such as the omikron subspecies BA.4 and BA.5 were found, which were more transmissible than the original strain. making the number of patients at present tends to continue to increase And in the future it is expected to gradually replace the original subspecies of omikron BA.2.

while the Ministry of Health has come out to admit The number of infected people is likely to actually increase. due to the relaxation of various measures

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Compilation of a list of “Thai medicines – modern medicines” that should be at home during Covid-19

coupled with the introduction of new mutant species but still within the criteria that can be supported by the public health Still moving forward to prepare to adjust the covid-19 to the next endemic disease

So if infected with covid will be treated and what drugs The New Media PPTV news team has compiled information from the Department of Medical Services documents. Ministry of Public Health subject Guidelines for medical practice, diagnosis, care and prevention of infection in hospitals. in the case of coronavirus disease 2019 (COVID-19)” Revised Edition 18 May 2022 There is information on the treatment of COVID according to the following symptom groups:

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Group 1 patients : No symptoms or few symptoms (Asymptomatic COVID-19)

The doctor will provide outpatient treatment. by isolating at home (Home Isolation : HI) or a place provided by the government and giving Andrographis paniculata at the discretion of the physician

Group 2 patients : Symptoms, but not severe, no pneumonia and no risk factors for severe disease

The doctor will consider favipiravir But if the patient has had symptoms for more than 5 days, antiretroviral therapy may not be necessary. because the patient will be able to heal on their own without complications

Group 3 patients : have mild symptoms but there are risk factors for severe disease (over 60 years of age, chronic obstructive pulmonary disease, cardiovascular disease, diabetes, obesity, liver cirrhosis, low immunity, HIV-infected)

Your doctor will recommend only one antiviral drug, which should be started within 5 days of the onset of symptoms. The criteria for choosing a drug are as follows:

  • If you have one risk factor, you may be given favipiravir, remdesivir, molnupiravir, or paxlovid.
  • If you have more than 2 risk factors, you may be given remdesivir, paxlovid or molnupiravir.

However, if receiving remdesivir It will be the only medicine that your doctor will prescribe for 3 days.

Group 4 patients : have pneumonia

Your doctor will recommend remdesivir for 5-10 days or a corticosteroid. depending on clinical symptoms

Insights into medical information

Andrographis paniculata

Andrographis paniculata There are both capsules or tablets containing Andrographis andrographis extract (Extract) or crushed powder (Crude Drug), which must be taken to obtain Andro. (Andrographolide) 180 mg/person/day divided into 3 doses before meals and administered for 5 consecutive days after infection only. (If the number of capsules per serving is large, it may be divided into 4 times a day.)

For andrographis paniculata suitable for adults because in the child There isn’t enough information to recommend it for the treatment of COVID-19.

As for the precautions of the thieves’ fading pills, they are as follows:

  • Do not use in people with a history of allergic reactions to Andrographis paniculata. and pregnant/lactating women Because it can affect the Uterine Contraction and the baby at birth.
  • Do not use with antihistamines. and medications that prevent blood clotting, such as warfarin, aspirin, and clopidogrel, because they may work together.
  • It should not be used with other antiviral drugs.
  • No dosage adjustments are available in patients with severe kidney disease or liver disease.
  • When Andrographis paniculata is used, abdominal pain, diarrhea, nausea, heart palpitations, loss of appetite, dizziness (more common with high or long-term use) or hives may occur (rare).

favipiravir (Favipiravir)

For the administration of favipiravir In adults, if the body weight is less than 90 kg, 1,800 mg (9 tablets) on the first day, 2 times a day, and 800 mg (4 tablets) twice a day, and in cases that weigh more than 90 kg. The first day is given 1000 mg (5 tablets) twice a day.

In children, 70 mg/day is given on the first day twice a day and on the following days it is given 30 mg/day twice a day.

The precautions for favipiravir are as follows:

  • Potential for abnormal fetal development (teratogenic effect). Caution should be exercised during use in pregnant women.
  • May increase uric acid levels Caution should be exercised in combination with the anti-tuberculosis drug “pyrazinamide”.
  • Beware of hypoglycemia (hypoglycemia) if used with repaglinide (Repaglinide) or Pioglitazone
  • Divide or crush the pills. and can be given through the nostrils (NG tube).
  • chronic kidney disease patients Dosage adjustment is not required. however, the dosage should be adjusted in patients with moderate to severe hepatic impairment: 4 tablets twice daily on the first day, and 2 tablets twice daily on the following day.
  • The drug should be administered within 4 days of the onset of symptoms for better results.

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Molnupiravir (Molnupiravir)

For the administration of molnupiravir In adults, 4 tablets of 200 mg/tablet should be given twice a day, and in children, it is currently only approved for use by people 18 years of age or older at risk of contracting COVID-19. only violent

The precautions for molnupiravir are as follows:

  • Potential for abnormal fetal development (teratogenic effect). Caution should be exercised during use in pregnant women. and lactating women
  • Dosage adjustment in patients with hepatic impairment is not necessary.
  • The drug must be administered within 5 days from the onset of symptoms to be effective. reduce hospitalization or death by 30 percent

Paxlovid (Nirmatrevir/Ritonavir)

For the administration of Paxlovid In adults, 2 tablets of Nirmatrelvir 150 mg/tablet plus Ritonavir 100 mg/tablet should be taken twice daily.

For children, it is currently only approved for use by people aged 18 and over who are at risk of COVID-19. only violent By using the same dosage as an adult.

The precautions for Paxlovid are as follows:

  • Do not use in pregnant women. and lactating women because there is no information
  • When used, there may be interactions with many other drugs such as ergot, statins, and amiodarone.
  • The drug must be administered within 5 days from the onset of symptoms to be effective. Reduces the incidence of severe symptoms by 89%

Include medicine to treat coviral-19. Open the criteria. Solve the doubts why each person receives differently.

Include medicine to treat coviral-19. Open the criteria. Solve the doubts why each person receives differently.

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