Pets are just as prone to diabetes as we are. Currently, diabetes in dogs and cats is found in 5 to 10%, and insulin injection therapy is not very effective.
Faculty of Veterinary Medicine Research Team Chulalongkorn University Therefore, together with Bio ink Co., Ltd., a spin-off company of Chulalongkorn University, developed a method for generating canine pancreatic cells from stem cells. and the first successful cell transplant technology in the country Aimed at testing on laboratory animals and sick animals. for further use in the treatment of diabetic animals
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“Diabetes in humans and pets are similar to some extent. But the knowledge of diabetes treatment in animals and humans is still very distant. Nowadays, the treatment of diabetes in humans tends to use stem cells and advanced technology. Therefore, we are trying to use this technology to develop treatment in animals as well.” Assistant Professor Dr. Jenpop Sawangmek, Department of Pharmacology. Faculty of Veterinary Medicine, Chulalongkorn University and co-founder of Bio Inc., discussed their motivation for developing a method for generating canine pancreatic cells from stem cells.
For ‘diabetes’ is a chronic, incurable disease. If there are complications caused by the disease, it can lead to the death of pets. or if unable to control sugar In the long run, it will result in the deterioration of various organs in the body causing suffering for pets and their owners. including the burden of expenses for pet owners
Asst.Prof.Dr.Dr.Janepop Sawangmek
Stem cell innovation research Successful treatment of diabetes in animals
Asst. Prof. Dr. Janaphop explains that most canine diabetes is type 1 diabetes. The body lacks beta-cells, which are cells used to make insulin. resulting in a lack of insulin in the body For type 2 diabetes, which is mainly found in cats, the body still has beta-cells but is impaired in insulin secretion. or have insulin resistance There are different treatments for both types of diabetes.
Dr. Sirirat Nanvisai and Dr. Watchareewan Rodprasert, co-founder of Bio Inc. Co., Ltd., provided additional information that For this research, the Veterinary Stem Cell and Bioengineering Innovation Center (VSCBIC) Research Unit, Faculty of Veterinary Medicine, Chulalongkorn Current diabetics using insulin injections to dogs are not very effective.
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In our research, we created a dog’s pancreatic cells. or may be called insulin synthesis cells (insulin-producing cells, IPCs) These are pancreatic cells induced from canine mesenchymal stem cells (cMSCs). with the development of implantation technology to replace damaged or destroyed pancreatic cells by the cells that produce this It has the ability to create and secrete insulin efficiently.
Dr. Watchareewan added that The method is used in conjunction with cell transplant technology developed using double encapsulation technology. make cells healthy Protect cells from deterioration and damage. Including resistance from the immune system as well.
“Diabetes is an incurable disease. Knowledge over the past 10 years has shown that stem cells can replace other cells in the body. Therefore, using existing knowledge to create specific cells by induction process in the laboratory. together with cell transplant technology with a focus on testing in laboratory and sick animals in the next phase The team aims to cure diabetes. Reduce complications during treatment,” said Dr. Watchareewan.
Dr. Watchareewan Rodprasert
‘Stem cells’ Hope for the treatment of diseases in animals and people
The research team is now able to develop cells from dog tissues. taken to separate stem cells raise the number and succeeded in establishing a cell induction process. with implant technology This platform has successfully tested the safety performance of the whole cell. and delivery systems in laboratory and sick animals It is expected that no more than 3 years will go into the actual treatment process in the animals.
Stem cells can be used in a wide variety of applications. If we can make cells from stem cells In the future, every organ in the body will be replaced by cells or tissues. We are currently conducting studies alongside bone prosthetics to replace damaged bone or accelerate bone repair. Including corneal surgery in dogs, which was studied in collaboration with the Faculty of Medicine. and the Faculty of Engineering, Chulalongkorn University
Stem cell technology is the hope for the treatment of diabetes and other diseases, and the success of the treatment of pets will also transfer the technology to treat people.
Stem cell-based pharmaceutical products for the treatment of disease
from the knowledge of bioengineering and stem cell technology, VSCBIC research unit, Faculty of Veterinary Medicine, Chulalongkorn For use in the treatment of pets in the near future, such as a product made from cells called Exosome Product, using technology developed to make a pharmaceutical that can be used to treat sick animals. or into the organs to repair and restore damaged or damaged organs
It can also be applied to treat other diseases such as cancer, liver disease, kidney disease, and diseases caused by organ degeneration, infection or immune disease. It is expected to be ready for animal testing within this year and within two years it will be commercially available for further therapeutic use in sick animals.
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