until it changes to a certain level and then jump back into the human population with changes that humans have never encountered before.
The team analyzed different sites for omikron-specific alterations and binding to the mouse ACE2 receptor protein, which occurred relatively. specific, leading to such assumptions
It is interesting that…if this assumption is true “Strange-looking species” may be ready to create more challenges for us in the future. and in a very unpredictable manner The above information is the result of a study recently published in the journal PNAS. Dr. Anan Chongkaewwatana Virologists NSTDA reflected on academic data further that
Another study came out of a Harvard University team on the response. A second-generation “COVID-19 vaccine” in the United States that is a combination of 50% mRNA of Spike original strain and 50% of BA.5 strain was given to volunteers as a booster. Compared to the vaccinated group, the original vaccination regimen lacked the mRNA of spike BA.5.
It can be summarized as follows. One…both vaccine formulations tended to activate very high antibodies against older strains and less against omikron strains (BA.1, BA.2 and BA.5).
Next…when considering immunity to BA.5 in the old vaccine booster group increased from 184 to 2,829 and in the second formulation vaccine group, increased from 211 to 3,693, or 15 times and 17 times respectively, which the team Research looks at The difference in mRNA presence of BA.5 spikes should be greater.
Third…when comparing the Pfizer…Moderna formulation 2 vaccines, it was found that there was no significant difference in inducing immunity to omikron, especially BA.5, but the Moder group. The field stimulates immunity to the original species higher.
Four…the binding values of antibodies and other values No difference was found between the two groups (antibody levels) such as ELISA.
Fifth… T-cell activation After the stimulation needle was not high and the difference was barely noticeable.
Six…Memory B cell responses to BA.5 spikes were not different in both groups.
The old vaccine group got 0.079% and the new vaccine 0.091%. At this point, the research team concluded that both vaccines activate the antibodies equally well. but not very good at stimulating T cells
In addition, the research team thinks The body has received many old formula vaccines. The body does not respond well to the new vaccine formulation. It may be an issue that requires serious consideration.
Another interesting data: The US CDC published data on the effectiveness of the booster vaccine (spike 3) on preventing hospitalization during the omikron outbreak among immunized populations over 18 years of age in hospital samples. Nurses in many US states have found…
Vaccine effectiveness declines rapidly within 120 days or 4 months.
During the BA.1/BA.2 outbreak the numbers dropped from 79% down to 41%, and during the BA.4/BA.5 the initial numbers were not the same as the previous outbreak wave, at 60% and lower. down to only 29% within 120 days after receiving the booster Which the research team said was a sharp drop in numbers.
“This document also mentions the 4th needle stimulation, but the data after 120 days is not enough to calculate the efficacy. But if we compare the trigger value is 61% in both periods of the current outbreak. The number that will drop will be slower or faster than the group of 3 needles, the remainder shouldn’t be that high anyway.”
aimed at surveillance “New species” Of the viral “COVID-19” that has changed, it is now much more than a year or two ago from the technology that had to decrypt the virus to see the virus change. which is time consuming and expensive Now new innovations come out to solve such problems in many ways.
If any technology is easy to develop less time Not wasting a lot of budget This is likely to be the deciding point that plays an important role in monitoring the rapidly growing new species in the future. And it is something that can be extended to other pathogens in the future as well.
reinforcing the understanding of the mechanism of “T cells” Unlike “antibodies”, T cells do not protect against infection. but will act to inhibit the effects of infection from spreading A sharp drop in antibodies will result in easy reinfection. But the symptoms of the disease are not severe. This is because the re-infected virus is immune to the body.
…prevents the virus from multiplying as high as when first infected.
“When a virus enters a cell The virus multiplies itself in the cell in large numbers. Viruses have to make their own proteins to assemble their offspring and other proteins that function to make new particles more efficient.”
Some of the viral proteins that are produced are then cut into small pieces by the host’s cells. and transported through a molecule called MHC to the cell surface. It’s like a flag that says this house is not safe anymore. It’s attacked. If you don’t hurry to deal with this house, it will be a source of many enemies to come out and attack other houses.
“T cells” There is a mechanism to quickly see flags that are pinned to the cell surface. But not all T cells will see the same color flag. If it’s a brand new flag, it’s never been used before. T cells won’t recognize them and let the virus gleefully multiply in that house. It will take some time for T-cells to learn and begin to deal with them. which…usually takes a long time
and in the event that the virus can increase the amount to destroy important parts of the body It can be severe, but if the virus does little damage. And the body can handle it immediately. “T cells” will have memory and ready to fight that virus the next time…“If the next infection is still the same virus. Although there were some key mutations that escaped antibodies to infect cells, most of the proteins that were made had remained the same. being sub-soiled to be flagged at the cell surface This time, T-cells are already waiting for battle. would be able to quickly destroy the house that was planted with the flag…”
“virus” Maybe a few particles were created, the house was already destroyed. The symptoms of infection can be controlled… Infected but no symptoms or very little from the functioning of T cells.
Currently, there is no “SARS–CoV-2” that has changed so much that the “T cell” is unknown…but the vaccine is created from just spikes. which has a limitation that the digested proteins are just spike proteins. But not all viral proteins result in less T cell activity from vaccines than those from natural infections.
If the infection in nature continues to increase, the chances of getting SARS-CoV-2 are very severe. will become more and more difficult Because T cells are harder to escape than antibodies. But the virus may not allow itself to give up easily. because there are often clever mechanisms To escape the capture of “T cells” or destroy. “T cells” yourself
Of course, this battle…is something to keep an eye on.
