2024-07-15 15:00:00
Early exposure to antibiotics can cause long-term vulnerability to asthma. This is confirmed by an investigation of the Monash University (Australia) which was published in the magazine ‘Vaccine‘.
In addition, the researchers isolated a molecule (IPA) produced by intestinal bacteria that, in the future, could be tested as a simple treatment in the form of a nutritional supplement for children at risk of asthma. , with the aim of preventing the development of the disease.
Asthma affects more than 260 million people worldwide and causes around 455,000 deaths annually.
The discovery of this molecule, produced by bacteria in the healthy gut, provides an explanation for why frequent antibiotic use increases the risk of asthma, he said. Ben Marsland, research manager. “We know that frequent antibiotic use early in life disrupts healthy gut microbiota and increases the risk of allergies and asthma. “We have discovered that the result of antibiotic treatment is a reduction in the bacteria that cause IPA, thus reducing a key molecule that has the ability to prevent asthma,” he said.
The first years of life are important to develop a stable gut microbiota. Marsland explains “it is first created by the intake of food – both milk and solid foods – as well as genetics and environmental exposures. “Children at high risk for allergies and asthma have been shown to have altered gut microbiota and developmental delays.”
The first years of life are important to develop a stable gut microbiota
According to the researcher, “the use of antibiotics in the first year of life can have the unexpected effect of reducing health-promoting bacteria, and we now know from this study that antibiotics cause a reduction in IPA, which we have . see is important early in life as our lung cells maturethat makes it a candidate for early prevention of airway damage.
Working with mice predisposed to develop asthma, the team found that – when treated with antibiotics early in life – the mice were more susceptible to allergic airway inflammation caused by the no dust, and this susceptibility is maintained until adulthood. Asthma is often triggered by exposure to dust mites.
Microbiota
This weakness is maintained in the long term, even after gut microbiota and IPA levels return to normal, indicating that the function of this molecule is important early in life.
When these mice’s diets were supplemented with the IPA molecule early in life, the researchers found that the mice were effectively led to develop dust mite allergic inflammation, or asthma, in adulthood.
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