DECRYPTION – More specific than immunosuppressants, they would make it possible to overcome the numerous adverse effects associated with these drugs.
The arrival of immunosuppressants, with cyclosporin in 1982 then tacrolimus in 1995, made it possible to develop organ transplantation, mainly kidney transplantation, by permanently blocking graft rejection. France has more than 40,000 kidney transplant recipients according to the Biomedicine Agency, a figure that is constantly increasing.
But immunosuppressants have serious side effects: by greatly reducing the activation of immune cells, they facilitate infections, increase the risk of cancer, complicate vaccinations and « affect the functioning of other organs with an increased risk of cardiovascular problems and diabetes, but also long-term toxicity for the kidneys which compromises the lifespan of the grafts, by 14 years on average currently », specifies Pierre Marquet, director of the Inserm pharmacology and transplantation unit at Limoges University Hospital.
But new antibody-based treatments are arriving, which target many…
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