2024-07-04 11:25:03
Biocare, a company specializing in research and development of green tea ingredients, announced on the 4th that a paper proving the muscle strength improvement effect of fermented green tea extract was published in an SCI-level academic journal.
A research paper confirming the muscle strength improvement effect of fermented green tea, a new material developed by Biocare, passed the final review and was published in June in the online edition of ‘Food Science and Biotechnology’, an SCI-level academic journal of the Korean Society of Food Science and Biotechnology.
This research paper, which proved the effect of fermented green tea using Bacillus subtillis SST-9960 on improving muscle function, was conducted in collaboration with Professor Hwang Jae-kwan’s team from the Department of Biotechnology at Yonsei University, in collaboration with industry and academia. The research team confirmed whether green tea extract fermented with Bacillus subtilis inhibited muscle atrophy induced by immobilization, and compared the muscle atrophy treatment effects of non-fermented green tea extract (NFAE) and fermented green tea extract (FAE).
We administered fermented green tea extract orally to C57BL/6J mice, measured muscle strength, exercise performance, muscle mass and volume, and analyzed the effects on the PI3K/Akt pathway and inflammatory response. As a result, we confirmed that muscle strength, exercise performance, muscle mass, and muscle volume were improved.
Fermented green tea activated the PI3K/Akt and mTOR pathways, which are signaling pathways involved in protein production, and reduced MuRF-1 and Atrogin-1, which are protein degradation factors. It also reduced the mRNA gene expression of TNF-a and IL-6, which are inflammatory substances.
“Fermented deer antler extract (FAE) is more useful than non-fermented deer antler extract (NFAE) in preventing and alleviating muscular dystrophy, and we confirmed that the content and effectiveness of physiologically active substances increased through the fermentation process,” said Koh Bong-soo, head of the Biocare Research Institute. “We will devote ourselves to functional research on fermented deer antler using the power of fermentation and the unique characteristics of deer antler to discover differentiated functionality, such as immune functionality, in addition to muscle strength functionality.”
Meanwhile, Biocare is a research and development company specializing in green tea materials. It has its own technology to manufacture fermented green tea with muscle-improving functionality. It operates a manufacturing facility in Yangju, Gyeonggi-do that can produce 10 tons of fermented green tea per year. The manufacturing technology was certified as a new health technology (NET) by the Ministry of Health and Welfare in December 2022.
Reporter Yong-Seok Choi, Donga.com [email protected]
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2024-07-04 11:25:03