Blood type affects early stroke risk, study finds

by time news

People with blood from one of the A groups are more likely to suffer a stroke before the age of 60 than people with other blood types, research has shown.

The blood type describes a variety of chemicals which may be present on the surface of our red blood cells. The best known include those named A and B, which may be together (AB), separate (A and B), or not present (0).

determined by genes

Not only that, but even within these broad features there can be subtle variations as a result of different mutations in the genes responsible for this variety.

Thus, in a study published last year in the scientific journal Neurology researchers in the area of ​​genomics revealed a clear relationship between the A1 subgroup gene and strokes at an early age.

The finding was the result of a work gathering 48 previous genetic studieswhich in total brought together a cohort of about 17,000 stroke patients and 600,000 healthy controls, all of them aged between 18 and 59 years.

One group increases risk and another protects

A genome-wide search revealed two genome locations strongly associated with earlier risk of stroke; one of them, in particular, coincided with the point where the genes that determine the blood group.


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A second analysis on specific types of blood type found that people whose genome encoded a particular variation of group A (A1) had a 16% higher risk of suffering a stroke before the age of 60, compared to other blood types.

Rather, the authors found that there was one blood group, the 01, which seemed to have the opposite effect; these patients had a 12% lower risk than controls of suffering a stroke before the age of 60.

The researchers clarify that exactly why this blood type increases the risk of early stroke is unknown at this time, but they say it is probably related to factors in the blood coagulation such as platelets, the lining of blood vessels, or other circulating proteins.


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References

Thomas Jaworek, Huichun Xu, Brady J. Gaynor, John W. Cole, Christina Rannikmae, Tara M. Stanne, Lisa Tomppo, Vida Abedi, Philip Amouyel et al. The Early Onset Stroke Genetics Consortium of the International Stroke Genetics Consortium (ISGC) Neurology (2022) DOI: 10.1212/WNL.0000000000201006

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