Brain condition after drinking a lot of alcohol is similar to that of dementia patients

by times news cr
Photo = Getty⁢ Images Korea.

Evidence is ⁢mounting that excessive drinking is a major cause of Alzheimer’s‍ disease⁤ and can ⁤accelerate its‍ progression.

Alcohol use disorder (AUD) and Alzheimer’s disease have been found to show similar gene ⁤expression changes that affect brain inflammation⁢ and cell function. The researchers pointed​ out that​ this suggests that the molecular pathway between the two diseases⁣ may be shared.

According to Scitech Daily, a science media outlet, the Scripps Research Institute in the U.S. used ‌single-cell‌ transcriptomics⁢ to find that Alzheimer’s disease‌ and⁣ AUD show similar gene expression patterns and that alcohol use can​ worsen ‌the progression​ of ‍Alzheimer’s ‌disease.

Alzheimer’s disease is the most common disease that causes dementia, and 60-70% of all dementia cases‌ are ⁢believed to be caused by Alzheimer’s disease.

According‌ to the Alzheimer’s‌ Disease International (ADI),​ the ⁤number of Alzheimer’s disease patients ⁣worldwide is estimated to‍ increase from 55 million in ⁣2023 to 152​ million in 2050. The​ main risk factors for Alzheimer’s disease are aging and genetic⁢ factors, but several studies have shown⁢ that lifestyle, including⁣ alcohol use, can ​also be a⁤ factor that can influence the onset and progression of the disease. According to research, sleep disorders and nighttime light pollution are related to Alzheimer’s​ disease.

“We ‌discovered several cell‌ type-specific genes ⁣and pathways ⁤that are dysregulated in​ both Alzheimer’s ‍disease and alcohol. “This⁣ supports the hypothesis that alcohol use disorders can accelerate the progression of​ Alzheimer’s disease,” ⁢explained Pietro Paolo ​Sanna, PhD,‌ professor of ‍immunology and microbiology at The Scripps Research Institute.

Brain condition after drinking a lot of alcohol is similar to that of dementia patients
Photo = Getty Images Korea.

The study is ⁤said to be the first to use ​single-cell transcriptomics to compare changes associated with Alzheimer’s ‌disease and AUD in diverse populations of‌ human brain cells.

To investigate cell-specific gene expression ‍changes in Alzheimer’s disease, researchers used ribonucleic‌ acid (RNA) sequencing data from hundreds of thousands of individual brain cells from 75 early-, middle-, and late-stage Alzheimer’s ⁤disease patients and 10 non-Alzheimer’s disease ​patients. ⁢was analyzed. They then⁢ compared the Alzheimer’s disease ‌gene expression data with existing RNA sequencing data from AUD⁣ patients.

As a result of⁢ the ​analysis, both AUD and Alzheimer’s disease showed similar ⁢gene ⁤expression changes, including ⁣upregulation of inflammatory genes and pathways, disruption of cell signaling and cell death-related pathways, and changes⁤ in vascular cells.

“This study is a differential analysis of two diseases that cause ⁤cognitive decline,” said‍ Dr. Arpita Joshi, a researcher in Dr.⁢ Sanna’s lab. “This⁣ study improves our understanding of the three clinical stages of Alzheimer’s disease.⁢ “We emphasize that alcohol use ⁣disorder should be considered a ⁣risk factor for Alzheimer’s disease,” ​he said.

Researchers advised avoiding excessive drinking for healthy aging.

The ⁤research results were published⁢ in the neuroscience journal eNeuro.

참고자료:Transcriptional Patterns in Stages of Alzheimer‘s Disease Are Cell-Type–Specific and Partially Converge with‌ the ⁢Effects of Alcohol Use Disorder in ⁢Humans.
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Park Hae-sik,‌ Donga.com reporter [email protected]

⁤ ‍ ‌ ⁣ ⁤ ‍ ⁢ ⁤​ ⁤ <link ⁢rel="stylesheet" href="https://image.donga.com/

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The article discusses the growing evidence linking excessive alcohol consumption to the onset and ⁣progression of Alzheimer’s disease. Research from the Scripps Research Institute highlights that both alcohol use disorder (AUD) and Alzheimer’s disease exhibit similar gene expression changes, particularly affecting brain ⁢inflammation and cell function. These ⁣findings suggest a shared molecular pathway between the two conditions.

The study, which utilized single-cell transcriptomics, found comparable gene expression patterns in patients with Alzheimer’s disease and those with ​AUD.⁢ Key similarities included the upregulation of inflammatory genes, disruptions in cell signaling, and pathways associated with cell death. The researchers emphasized that ‌alcohol ⁤use disorder should be recognized as ⁣a potential⁣ risk factor for developing Alzheimer’s disease.

As Alzheimer’s disease⁢ is‍ a leading cause of dementia,​ with an estimated increase in global cases from ⁣55 million in 2023 to 152 million by 2050, understanding lifestyle factors like alcohol consumption is critical. Researchers recommend avoiding excessive drinking to⁤ support ​healthy aging.

The ⁤results of this ⁢study were ⁢published in the neuroscience journal⁣ eNeuro, contributing to a better understanding of the relationship‍ between alcohol use and ⁢cognitive decline.

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