Children with IBD have an increased risk of venous thromboembolism (VTE) compared to the general population, researchers from Erasmus MC, among others, found in an international cohort study.
The guidelines on thromboprophylaxis for VTE in children with inflammatory bowel disease (IBD) are based on limited pediatric evidence. In this study, the incidence of VTE in children with IBD was prospectively assessed. From October 2016 to September 2020, pediatric MDL physicians reported monthly to the International Safety Register whether they had observed a case of VTE in an IBD patient < 19 years of age.
An evaluation of nearly 25,000 children with IBD identified 20 cases of VTE. Of them, 30% had Crohn’s disease. This means that the incidence of VTE is 3.72 per 10,000 person-years. This is 14 times higher than in children from the general population (incidence of 0.27; p < 0.001). Brain sinus thrombosis was the most commonly reported (50%). All but 1 patients had active IBD, 45% used steroids and 45% were hospitalized. No patient received thromboprophylaxis, although current guidelines on IBD recommended it for 4 out of 20 patients.
Given this increased risk, awareness of the occurrence and prevention of VTE in all children with active IBD is needed, especially those who are hospitalized, the researchers said.
Bron:
Aardoom MA, Klomberg RCW, Kemos P, et al. The Incidence and Characteristics of Venous Thromboembolisms in Paediatric-Onset Inflammatory Bowel Disease: A Prospective International Cohort Study Based on the PIBD-SETQuality Safety Registry. J Crohns Colitis. 2022;16:695-707.