Citalopram: NHS Warns of 6-Week Rule & Risks

by Grace Chen

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LONDON, January 23, 2026 – Suddenly stopping antidepressants, even when you *feel* better, can backfire, health officials warn. The National Health Service (NHS) is urging anyone taking citalopram-a common antidepressant-to consult a doctor before discontinuing the medication, as doing so could worsen symptoms.

Don’t Ditch the Pills Too Soon: Why Stopping Antidepressants Needs a Doctor’s OK

A sudden halt to antidepressants like citalopram can undo progress and lead to a relapse, according to the NHS.

  • Citalopram, an SSRI, works by increasing serotonin levels in the brain to improve mood and sleep.
  • It typically takes 4-6 weeks to experience the full benefits of citalopram,so patience is key.
  • Stopping the medication abruptly can cause withdrawal symptoms and a return of depression.
  • Individuals with diabetes need to monitor blood sugar levels closely when starting citalopram.

So, what’s the deal with citalopram? This medication falls into a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). It works by boosting levels of serotonin, a neurotransmitter that plays a crucial role in regulating mood, emotions, and even sleep. But simply *feeling* better isn’t a green light to stop taking it.

The Six-week Rule: Give It Time to Work

The NHS emphasizes that it usually takes between one and two weeks for citalopram to begin showing effects, but the *full* benefits aren’t typically felt for four to six weeks. “Do not stop taking citalopram after 1 or 2 weeks just because you feel it is not helping your symptoms. Give the medicine at least 6 weeks to work,” the NHS states.

Q: Can stopping citalopram early make things worse?
A: Yes. The NHS warns that discontinuing citalopram prematurely can lead to a return of depressive symptoms or even worsen your condition. It’s crucial to follow your doctor’s guidance for safely tapering off the medication.

Interestingly, starting citalopram can also come with a temporary increase in anxiety, particularly when treating panic attacks. The NHS notes that this usually subsides within a few weeks, but advises consulting a doctor if it persists, as a lower dose might be helpful.

Potential Side Effects: What to Watch For

Like all medications, citalopram can cause side effects.Common ones-affecting more than 1 in 100 people-include a dry mouth, excessive sweating, difficulty sleeping, fatigue, headaches, and nausea. Though, more serious side effects are rare, occurring in less than 1 in 1,000 people.

when to seek medical attention:

  • Book an appointment: changes in menstrual cycles (heavy bleeding,spotting),unexplained weight gain or loss.