On March 24, 65, Veterinarian Sorawit Thanito, Director-General of the Department of Livestock Development Revealing the progress of the production of Lumpia vaccine Skins in cattle-buffaloes for use in emergency prevention and control by the vaccine development unit of the Department of Livestock Development The results of the preliminary efficacy trial were comparable to that of foreign vaccines. It is expected that the first batch of vaccines will be completed in mid-May 2022 at a cost of 9 baht each, which reduces the cost of disease prevention for farmers. And it will create stability in Thailand’s vaccine as well.
Director General of the Department of Livestock Development added that From the problem of Lumpy Skin Disease in cattle-buffaloes (Lumpy Skin Disease): LSD, which is an emerging disease in 2021 for the first time in Phanom Phrai District. Roi Et Province on March 29, 2021, which the Department of Livestock Development has joined with all sectors, including the governor of every province. local government organization Including farmers and people, implementing 5 important measures for effective control of Lumpy Skin Disease in cattle and buffaloes, namely: 1. Controlling the movement. 2. Closely monitor the occurrence of the disease. 3.Prevent and control disease-carrying insects 4. Treating sick animals according to symptoms and 5. Using vaccines to control disease. by importing vaccines from abroad to be used to control the disease to calm quickly For vaccines used to prevent disease in the past need to import vaccines from abroad The Department of Livestock Development has imported 5.3 million doses, with a budget of more than 160 million baht, and the private sector, associations and farmers groups imported about 5 hundred thousand doses, worth about 22.5 million baht, which is a total value of more than 180 million baht.
Therefore, in order to reduce the cost of disease prevention for cattle and buffalo farmers and to create stability in vaccines, Dr. Chalermchai Sri-on, Minister of Agriculture and Cooperatives, has instructed the Department of Livestock Development to research and develop a lumbar disease vaccine. Year Skin Department of Livestock Development by the Bureau of Animal Biotechnology and the National Institute of Animal Health, which are 2 government agencies within the Department of Livestock Development. who have the knowledge and personnel who have expertise in vaccine production Conducting a feasibility study on the production of Lumpy Skin vaccine for emergency prevention and control. Has started to develop vaccines at the laboratory level (Lab scale) since May 2021 by the National Institute of Animal Health. The virus was successfully isolated from domestic sick animal samples for laboratory culture. and send the virus head to the Bureau of Animal Biotechnology used to amplify the viral load in cell cultures and produce inactivated antigens to cause disease After that, two vaccine formulas were produced: inactivated inactivated vaccine in liquid form and inactivated inactivated vaccine in oil form. The results of animal testing according to the standard method of vaccine production. It has been shown that both vaccines are safe and do not cause allergic reactions in animals. and oil-type vaccines provide 100% protection, higher than water-based vaccines that provide 80% protection. Oil-type vaccines continue to provide protection until the 7th month, which the Department of Livestock Development will continue to test for disease protection until complete 12 months
For the field trial of vaccine efficacy in December 2021, the Department of Livestock Development has cooperated to bring the oil-type vaccine prototype to be tested in Farm Chokchai, Pak Chong District, Nakhon Ratchasima Province. by comparison with vaccines produced abroad. The preliminary test results showed that vaccines produced from foreign countries and vaccines produced by the Department of Livestock Development. It has a good immune stimulation effect.
Currently, the Department of Livestock Development has continued to expand the vaccine production capacity from the laboratory level (Lab scale) to the semi-industrial level (pilot scale) with production technology in cell culture bottles. which is the original technology for the production of foot-and-mouth disease vaccine And the Bureau of Animal Biotechnology has knowledge and skilled personnel. The aforementioned production technology can support the production of vaccines that 50,000-100,000 doses per month. Throughout the production process, it takes about 2 months and is expected to produce the first batch of vaccines to be completed around mid-May 2022 at a cost of 9 baht each during the first year (June 2022. – May 2023) A vaccine can be produced with a value of 6 million baht. If imported from abroad, a budget of 27 million baht will be required, which will save up to 21 million baht in the state budget.
However, in order to have enough vaccines to meet the needs for domestic control and prevention. including animals imported from neighboring countries The Department of Livestock Development has conducted a feasibility study to expand the production capacity of Lumpy Skin Disease Vaccine, inactivated media type oil. by using large scale roller or Microcarrier technology to be able to produce 5 hundred thousand to more than 1 million doses per month. The results of the study will be known in the middle of 2023 if the production capacity meets the target set. It will be able to reduce the importation of vaccines from abroad by up to 8 million doses per year, which requires a budget of 360 million baht. Therefore, the Department of Livestock Development can produce the Lumpy Skin vaccine itself will help reduce the cost that Must be imported from abroad for more than 280 million baht per year and can also be sold to neighboring countries in ASEAN as well. In addition, thorough vaccination will lead to the permanent elimination of Lumpy Skin Disease from Thailand in the future.