COVID Drug VV116 Shows Promise Against Nipah Virus | Study

by Grace Chen

WUHAN, China, 2026-01-29 05:05:00

Promising Drug Shows Potential Against Deadly Nipah Virus

Lab tests and animal studies reveal a new antiviral, VV116, offers a potential defense against the rare but highly lethal Nipah virus.

  • VV116 demonstrated comparable effectiveness to remdesivir in laboratory settings.
  • In hamster studies, VV116 boosted survival rates to 66.7% after three weeks, compared to zero survival in the control group.
  • Researchers suggest VV116 could be used preventatively for high-risk groups like healthcare and lab workers.

A new antiviral drug, VV116, is showing significant promise in the fight against the Nipah virus, a rare but devastating pathogen. Early research indicates the drug works as effectively as remdesivir in laboratory tests, offering a glimmer of hope in addressing this emerging infectious disease threat.

Viral Load Reduction Observed in Critical Organs

Beyond its effectiveness in lab settings, VV116 demonstrated a substantial reduction in viral loads within key organs – the lungs and brain – during animal studies. This suggests the drug’s active form effectively reaches these critical areas at therapeutic doses, hinting at a real possibility for impactful treatment if administered early in the course of infection.

What is Nipah virus? Nipah virus is a zoonotic virus – meaning it spreads from animals to humans – and is linked to severe respiratory illness and encephalitis (brain inflammation). It has a high fatality rate, ranging from 40% to 75%, depending on the outbreak.

Human Trials on the Horizon

The encouraging preclinical results are paving the way for further investigation. Researchers believe these findings strongly support the initiation of human trials to assess VV116’s safety and efficacy. The Wuhan Institute has even proposed exploring VV116 as a preventative measure for individuals at higher risk of exposure, such as healthcare professionals and laboratory personnel.

Vigonvita Life Science Co, the company developing VV116, stated that the preclinical data supports the drug’s potential as a Nipah virus treatment. They plan to closely monitor global outbreak trends and initiate clinical trials for both treatment and post-exposure prevention as needed.

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