Cut back the dimensions of fats tissue to reduce weight… Opens a brand new path for weight problems and diabetes remedy

2024-07-01 22:36:36

KAIST Analysis Crew Uncovers the Function of Proteins

Dong-A Ilbo DB

A home analysis staff has found a brand new weight problems remedy methodology that reduces weight by lowering the dimensions of fats tissue.

The Korea Superior Institute of Science and Know-how (KAIST) introduced on the first {that a} analysis staff led by Professor Website positioning Jae-myeong of the Graduate Faculty of Medical Science and Engineering and Professor Lim Dae-sik of the Division of Life Sciences has found a brand new remedy technique for metabolic ailments reminiscent of weight problems and diabetes.

The analysis staff targeted on the YAP/TAZ protein, which is concerned within the Hippo signaling pathway, which performs an vital function in figuring out the dimensions of physique tissues. By observing what function this protein performs in fats cells, they confirmed that when the YAP/TAZ protein is activated, the dimensions of fats tissue decreases.

When the precise analysis staff eliminated the genes (Lats1 and a pair of) that block the exercise of Yaptas from mice, they have been in a position to verify that the bodily measurement of the fats cells grew to become smaller. When Yaptas was repeatedly activated, the fats cells became a state (precursor) just like stem cells earlier than changing into fats cells. Because of this, the mice that have been overweight returned to regular weight.

The researchers additional revealed that Yaptas is instantly concerned in producing leptin, also referred to as the ‘satiety hormone’. It has been beforehand recognized that leptin is a key hormone that suppresses urge for food and will increase vitality consumption, however that is the primary time that it has been revealed how it’s produced on the molecular stage. In different phrases, activating Yaptas can enhance the quantity of leptin and likewise produce results reminiscent of urge for food suppression.

This research is important in that it opens up the potential of treating metabolic ailments reminiscent of weight problems and diabetes by activating the YAP protein in fats cells. This research was printed within the worldwide educational journal ‘Nature Metabolism’ on Might 29.

Reporter Choi Ji-won [email protected]

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2024-07-01 22:36:36