2023-05-17 03:30:33
Diabetes or obesity during pregnancy mean long-term consequences for the offspring: Children of sick women are genetically predisposed to these diseases. You can read how here.
A study shows that children born to women during pregnancy obese were or on Diabetes suffered, have epigenetic changes that make them responsible for these very diseases predispose – and thus also for the resulting Cardiovascular problems.
„Die pregnancy is an important cornerstone that actively influences the development of the offspring and their predisposition to the later occurrence of cardiometabolic diseases,” explains research group leader Empar Lurbe. “Diseases such as maternal obesity and gestational diabetes can impair the health of offspring from infancy to adulthood and increase the risk of comorbidities that affect quality of life and life expectancy.”
influence on the genome
Obesity during pregnancy affects up to 30% of pregnant women. “Apart from the epidemiological findings, the molecular causes responsible for negative effects on the health of the offspring are unknown,” says Mario Fraga. The scientist and his team therefore wanted to analyze the epigenetic changes in the offspring that are related to the mother’s metabolic status during pregnancy. To do this, the researchers also observed the children of mothers obesity or with obesity and gestational diabetes throughout the first year of life. This enabled them to clarify how the mothers By change and influence their descendants on a molecular level in the long term.
Environment and genes interact
The results indicate that the health status and the metabolic status of the pregnant mother permanently influences the health of the offspring. The intrauterine Environment and in particular obesity and gestational diabetes can methylation pattern permanently reprogram the children. The changes affect genes that are part of the regulatory pathways of the fatty acid metabolismcardiovascular signaling or the mitochondrial Bioenergetics are – crucial processes in obesity and diabetes mellitus.
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The ability to detect these changes in peripheral blood supports the idea that maternal metabolism has systemic effects on child development. According to the authors of the study, it is now important to develop prevention strategies that lead to an improvement in the general health of the population.
This text is based on a press release des Consortium Center for Biomedical Research in Network MP. Here you can find the original publication.
Image source: Mon Petit Chou Photography, unsplash
#Diabetes #obesity #Danger #child