“Dr. Anan” reveals US research. The H5N1 avian influenza virus was found to cause damage to the brain, and the animal died within a week, reflecting a more severe mutation.
Dr. Anant Chongkaewwatana Director of Animal Health Innovation and Management Research Group National Center for Genetic Engineering and Biotechnology (Biotech) posted a Facebook page. Anan Jongkaewwattana Keep an eye on the H5N1 avian influenza virus that mutates and affects the brain by stating that
The H5N1 avian influenza virus has been found in many European countries. and the United States long enough The virus is not static because it can exchange genetic material with other local strains of avian influenza viruses.
The opportunity for the H5N1 virus to mutate by acquiring genetic fragments to enhance its own effect therefore occurs.
Today a study was published in the journal Nature Communications. by a research team at St. Jude Children’s Research Hospital in the United States
The research team studied H5N1 avian influenza viruses isolated from two poultry species: Wigeon/SC/21 from ducks in December 2021 and Eagle/FL/22 from eagles in February 2022, three months apart.
Both viruses share the same HA and NA H5N1, but Eagle/FL/22 has a different gene (PB2,PB1, NP). believed to have been exchanged from other strains of the virus
The research team subjected two H5N1 strains to a virulence test in Ferret, a representative animal model of mammals.
The test results showed that the original H5N1 virus from ducks still did not do much to Ferret, which was evident from the less severe symptoms. and the relatively low amount of virus in Ferret’s body This indicates that the virus still has a barrier between different species. between poultry and mammals
But the H5N1 virus isolated from eagles The severity effect in Ferret is clear. The virus can infect and cause the Ferret to become severely ill within 1 week. The viral load found in the organs of the infected Ferret was very high.
The most surprising thing is Finding a virus in Ferret’s brain is something unusual. for animals infected with influenza virus
The research team believes that H5N1 in nature now There are changes that are quite sensitive. There is a high risk of changing the virus properties from the past.
For example, an infection can affect the nervous system or brain. This will significantly increase the severity of the virus. I have to keep a close eye on it.
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