# Eczema Linked to Increased Risk of Crohn’s Disease and Keratitis, New Study Finds
A new study published in Nature Communications reveals a notable association between atopic eczema, a common skin condition, and an increased risk of developing Crohn’s disease and keratitis, potentially broadening teh understanding of the condition’s systemic impact. The findings underscore the importance of considering eczema as a potential risk factor for other chronic health issues, particularly in young people.
eczema, also known as dermatitis, is characterized by dry, itchy, and inflamed skin, impacting the daily lives and psychological well-being of millions. Estimates from GlobalData epidemiologists support the condition’s prevalence in the UK, wiht forecasts predicting a rise in diagnosed cases from 5,070,000 in 2026 to 5,170,000 by 2033.
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Traditionally understood as an atopic disease – a genetic predisposition to allergic conditions like asthma – research into eczema’s connection to non-allergic conditions has been limited.This new research, however, sheds light on potential comorbidities. Researchers analyzed nearly 25 years of diagnosis and prescription records, spanning from 1997, from over three million individuals in England using the Clinical Practice Research Database. Participants with and without eczema were carefully matched based on age, sex, and general practice to ensure a robust comparison.
While allergic conditions were the most common comorbidities observed, the study revealed a striking correlation between eczema and two specific inflammatory diseases. Individuals with eczema were found to be 70% more likely to develop Crohn’s disease during the study’s follow-up period compared to those without the skin condition. A similar 70% increased risk was also observed for keratitis, an inflammatory condition affecting the eye’s cornea.
Age Matters: Young People Face Highest Risk
The heightened risk was particularly pronounced in younger individuals.When the results were analyzed by age group, those aged 18 or younger with eczema exhibited the largest increase in risk for both Crohn’s disease and keratitis compared to any other age demographic. This finding highlights the potential for early intervention and preventative strategies in this vulnerable population.
Both Crohn’s disease and keratitis can have severe, long-term consequences if left unmanaged. Crohn’s disease, an incurable inflammatory bowel disease, can lead to life-threatening complications.similarly, untreated keratitis can result in blindness.
Implications for treatment and Prevention
“This study presents an important finding in understanding the potential implications of an atopic eczema diagnosis across the life course,” one analyst noted. The research suggests a need for further examination into the shared underlying mechanisms between eczema and these other chronic conditions, which could reveal novel therapeutic targets.
Given the high prevalence of atopic eczema in the UK, a deeper understanding of its role as a risk factor for other chronic health outcomes could considerably improve care and prevention efforts, ultimately mitigating the overall burden of chronic disease. Further research is crucial
