2023-09-13 08:48:32
Exercise Can Help Prevent Alzheimer’s Disease, Study Finds
Multiple studies have already indicated that physical activity can have a preventive effect against Alzheimer’s disease. Building upon this existing body of research, a team of scientists from Massachusetts have now uncovered the mechanism behind this phenomenon. The researchers discovered that exercise triggers the release of a muscle protein called irisin, which effectively breaks down Alzheimer’s plaques in the brain.
Through a series of experiments using cells, the scientists observed that irisin decreased the presence of Alzheimer’s plaque deposits. In a subsequent stage, they managed to elucidate the process behind this response. It was discovered that irisin activates an enzyme known as neprilysin, which is released by astrocytes, a specific type of brain cell. Neprilysin is responsible for breaking down amyloid beta, a protein associated with Alzheimer’s disease. Furthermore, the researchers identified the receptor through which irisin binds to astrocytes, stimulating the production of neprilysin. Additionally, they identified two signaling pathways involved in the process.
The groundbreaking mechanism, described in the journal “Neuron,” could potentially pave the way for the development of irisin-based therapies for Alzheimer’s disease. By understanding the receptors and proteins involved, researchers now have potential targets for therapeutic interventions. Notably, irisin has demonstrated the ability to travel from the bloodstream to the brain in mice, suggesting it could directly be used as a therapeutic agent.
Irisin is a hormone primarily released by muscles during exercise. Besides regulating glucose and lipid metabolism in fatty tissues, it also provides energy. Previous studies have revealed the presence of irisin in the brain, and researchers have noted reduced levels of irisin in both humans and mice with Alzheimer’s disease.
This groundbreaking research offers new insights into the potential benefits of exercise in preventing Alzheimer’s disease. By understanding the underlying mechanism, scientists may be able to develop innovative treatments that could have a significant impact on this debilitating condition. The study conducted by the Massachusetts research team is published in the journal “Neuron.”
Source: DOI 10.1016/j.neuron.2023.08.012]
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