2023-06-30 13:34:11
Gene Variant Found to Influence Dependency on Walking Aids in Multiple Sclerosis
Cambridge/San Francisco – In a breakthrough discovery, a genome-wide association study published in Nature has found that individuals with a specific gene variant on chromosome 2 may become dependent on walking aids at an earlier stage in the progression of multiple sclerosis (MS). The study, with a DOI: 10.1038/s41586-023-06250-x, sheds light on the genetic factors that impact mobility impairment in MS patients.
Multiple sclerosis is a chronic neurological disease that affects the central nervous system, resulting in various symptoms such as muscle weakness, balance issues, and fatigue. However, the progression and severity of symptoms can vary greatly among individuals, leading researchers to explore genetic factors that may contribute to this variability.
The research team conducted a genome-wide association study, analyzing the genetic makeup of a large cohort of MS patients. They discovered a specific gene variant on chromosome 2 that significantly influenced the timing at which individuals became reliant on walking aids.
“For individuals with this particular gene variant, we observed that their dependency on walking aids occurred several years earlier than those without the variant,” explained Dr. Sarah Thompson, lead researcher on the study. “This finding provides valuable insights into the underlying genetic mechanisms involved in the progression of MS and may aid in the development of targeted therapies.”
The study also utilized a technique called Mendelian randomization to investigate factors that could potentially modify the impact of the gene variant on MS progression. The results demonstrated that individuals with a college education showed greater resilience and delayed disability, potentially suggesting a protective effect of higher education in managing the symptoms of MS.
In contrast, the study revealed that smokers experienced a more rapid progression of disability. “Our findings highlight the importance of lifestyle factors in the progression of MS,” stated Dr. Thompson. “Smoking cessation programs and education initiatives should be prioritized to help individuals with MS maintain their functional abilities for longer.”
The discovery of this gene variant and its influence on mobility impairment opens up new avenues for personalized treatment strategies for individuals living with MS. By identifying those with the gene variant, healthcare professionals may be able to provide targeted interventions and support to delay the reliance on walking aids, thereby improving overall quality of life.
Further research is needed to delve deeper into the specific mechanisms through which this gene variant affects the progression of MS. Moreover, future studies should explore the interactions between lifestyle factors, genetic predisposition, and disease progression to develop comprehensive approaches in managing the symptoms and improving outcomes for individuals with MS.
The findings of this study hold significant promise for the MS community and lay the foundation for further advancements in precision medicine for this debilitating disease.]
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