While BA.5, the Ministry of Health identified on 14 September 2022, is the main species. The epidemic makes people sick the most in Thailand. Along with pointing out that BA.2.75.2, which spreads faster than BA.5, is 114%, not severe, but this time, a new BA.5 mutant named BQ.1.1 was found to have a speed of spreading. Most in the world (at the moment) even faster than BA.5.. up to 531%. Experts around the world. watch out
Medical Genome Center Faculty of Medicine Ramathibodi Hospital Mahidol University Post on Facebook, the Center for Medical Genomics revealed a report on the discovery of “BQ.1.1”, the great-grandson of Omicron BA.5. have a mutation The thorn region differs from BA.5 in three locations, R346T, K444T and N460K, likely to replace “BA.5” and “BA.2.75.2”.
Currently, the number of people who are immune to the 2019 coronavirus both from natural infections and from vaccination continues to increase worldwide causing the number of new infections and deaths around the world significantly reduced Many countries have adjusted their status to make COVID-19 an endemic disease.
Immunity in humans around the world with increasing is the driving force behind the virus must accelerate the mutation for survival especially the change thorn area the outer shell of the virus particle to evade immunity to be able to spread from person to person as long as
from the cooperation of “Scientists around the world in the digital age” joined together decode genetics Coronavirus-2019 whole genome uploaded and shared on database The global COVID genetic code “GISAID” allows us to know Global coronavirus 2019 mutation in real time.
while experts around the world monitoring Omicron Outbreak Subspecies “BA.2.75.2” found in India be the first country and spread all over the world by slowly replacing BA.5 and BA.4.6 It was able to detect Omicron, a new “great-grandson of BA.5” in England, named BA.5.3.1.1.1.1(.1) or “BQ.1.1”. (Picture 1)
omicron subspecies with mutations beyond the page and likely to replace the main species of Omicron BA.5 that are spreading all over the world at the moment are
BA.5.3.1.1.1.1(.1) / BQ.1.1
BA.2.3.20
BA.2.75.6.1 / BY.1
BA.2.75.5.1 / BN.1
BA.2.75.2
BA.5.2.1.7 / BF.7
by experts around the world Currently focusing on BQ.1.1 the most. due to the number of infected fast boost especially in england The first sample was detected on August 26, 2022. Currently (September 22, 2022) 28 cases have been found in the “GISAID” database, of which 78 cases have been found worldwide. Italy, Denmark, Belgium, Japan, Austria, Netherlands, Germany (Picture 2)
Omicron BQ.1.1, the great-grandson of BA.5, has a mutation on three thorn segments. The R346T, K444T and N460K are different from the BA.5 (Figure 3) and are identical to the BA.4 / BA.5 in four locations: 69 – 70 missing from the genome, L452R, R493Q, and F486V.
Omicron BQ.1.1 mutates on 6 thorn segments, different from BA.2.75.2. are 69 – 70 missing from the genome, L452R, K444T, G339D, and F486V (Figure 4).
It can be seen that the location of the mutation on the thorn in each subspecies start to be similar That is to say, there is an evolutionary nature. The form of “convergent evolution” is that of different species. But similar traits, such as the wings of birds, insects and bats, have evolved to respond due to their adaptation. specific environment (evade immunity)
Omicron BQ.1.1 has not been found in Thailand.
BQ.1.1 has an advantage in the growth-epidemic (relative growth advantage) about 5.3 times more than BA.5 (531%) (Picture 5)
and have an advantage in the growth – spread (relative growth advantage) Approximately 3.2 times more than BA.2.75.2 (327%) (Picture 6)
which can be considered It is a subspecies of omicron. capable in the fastest epidemic in the world right now the severity of symptoms of infection There was no significant difference from BA.5.
refer
Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution
https://www.biorxiv.org/content/10.1101/2022.09.15.507787v1
#BackboneMCOT
Reference and thanks for information from:
Facebook : Center for Medical Genomics
(Medical Genome Center Faculty of Medicine Ramathibodi Hospital Mahidol University)
https://www.facebook.com/CMGrama