2024-04-12 17:55:22
Research results have shown that if bowel movements are reduced and constipation occurs, the risk of developing Alzheimer’s increases.
According to the medical community on the 12th, research results from the Gwangju Institute of Science and Technology and the Digital Health Center of Kyung Hee Medical Center were published in the world-renowned general scientific journal ‘Journal of Advanced Research’. The research team determined that there is a causal relationship between decreased intestinal motility and Alzheimer’s disease.
This study is based on the ‘gut-brain axis’ theory, which views the intestines as the ‘second brain’. The theory is that if gut health deteriorates or the balance of microorganisms in the gut is disrupted, brain function and emotional state can also be affected. The research team went further and discovered a link between intestinal functional abnormalities and mental illness.
The research team administered loperamide, a type of antidiarrheal drug, to an Alzheimer’s mouse model. As a result, amyloid beta protein in the brain and immune cells in the brain increased significantly, and pathological phenomena such as memory decline appeared.
Additionally, among approximately 3.13 million Koreans and approximately 4.38 million Japanese patients, the risk ratio for Alzheimer’s disease in patients with constipation was confirmed to be 2.04 times higher in the Korean cohort and 2.82 times higher in the Japanese cohort than in patients without constipation.
Lee Eun-joo, head of the Department of Neurology at Seran Hospital, said, “The study showing that constipation can more than double the risk of dementia supports the claim that our body’s intestines and brain closely interact.”
“If we look at data from actual patients, we can see that Alzheimer’s disease can worsen if intestinal motor function declines,” he said. “Alzheimer’s disease, which accounts for the majority of dementia patients, causes cognitive dysfunction gradually, so it is important to prevent worsening in advance.” “He explained.
This study, which found that constipation can more than double the risk of dementia, supports the argument that our intestines and brain interact closely.
Alzheimer’s disease, commonly known as Alzheimer’s disease, is a neurodegenerative disease of unknown cause and accounts for more than half of all dementias. It is a disease in which numerous nerve cells in the brain gradually decline, leading to brain tissue loss and brain atrophy. Initially, problems appear in memory for recent events, but gradually they become accompanied by abnormalities in other cognitive functions such as language function and judgment.
Usually, Alzheimer’s progresses slowly over 8 to 10 years. It is important to treat not only cognitive decline but also mental and behavioral symptoms such as delusions, depression, anxiety, nervousness, and sleep disorders. In the case of terminal dementia, neurological symptoms and other physical complications occur, making it impossible to live independently, and many people die from complications such as fecal and urinary incontinence, bedsores, pneumonia, and urinary tract infections.
Kim Ye-seul, Donga.com reporter [email protected]
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2024-04-12 17:55:22