2023-10-06 17:50:00
New Guidelines Recommend Duloxetine as the Best Option for Chemotherapy-Induced Peripheral Polyneuropathy
A new set of guidelines from the American Society for Clinical Oncology (ASCO), the European Society for Medical Oncology (ESMO), and the Gynecological Oncology Working Group (AGO) have recommended interventions for the treatment of chemotherapy-induced peripheral polyneuropathy. However, the guidelines state that these recommended interventions are rare.
According to the guidelines, the best option for treating chemotherapy-induced peripheral polyneuropathy is to take duloxetine. A randomized study has demonstrated that duloxetine provides moderate clinical benefits compared to venlafaxine and placebo. Possible alternatives that may be considered include anticonvulsants and tricyclic antidepressants.
In addition to pharmacological interventions, the guidelines also suggest non-pharmacological measures such as physiotherapy and acupuncture. However, the evidence for scrambler therapy, which involves electronic stimulation of peripheral nerves, is currently not clearly established.
The guidelines also highlight that different topics related to treatment options are rated differently. Some interventions may fall under measures that can be considered, sometimes as part of studies. For example, topical preparations containing menthol, capsaicin, or combinations of baclofen/amitriptyline/ketamine or ketamine/amitriptyline were examined. However, the guidelines do not advocate drug prophylaxis for chemotherapy-induced peripheral polyneuropathy.
One potential treatment option that can be tried, possibly as part of studies, is cryotherapy. Further research is needed to fully understand its effectiveness in managing chemotherapy-induced peripheral polyneuropathy.
Overall, these new guidelines aim to provide healthcare professionals with evidence-based recommendations for the treatment of chemotherapy-induced peripheral polyneuropathy. By selecting the most effective interventions, healthcare providers can improve the quality of life for cancer patients experiencing this debilitating side effect of chemotherapy.]
#Cooling #prophylaxis #capsaicin #therapy