Hanmi Pharmaceutical participated in the American Obesity Society
Poster presentation of new concept obesity treatment research results
‘Game changer’ that overcomes the limitations of existing GLP-1 treatments
“Selective fat loss while increasing muscle”
“Differentiating efficacy from ‘Wegobi’ by capturing the yo-yo phenomenon”
Hanmi Pharmaceutical announced on the 6th that it announced the results of research on a new concept obesity treatment drug (HM17321) that achieves both weight loss and muscle gain at the American Obesity Week held last month.
It is evaluated that it has proven the potential of a ‘game changer’ that can overcome the limitations of glucagon-like peptide (GLP-1)-based drugs that inevitably cause muscle loss. GLP-1 type obesity treatment drugs are receiving a lot of attention around the world. Novo Nordisk WiGobee (ingredient name: semaglutide), which was recently released in Korea, is causing a shortage.
Choi In-young, head of Hanmi Pharmaceutical R&D Center, said, “HM17321 is an innovative obesity new drug designed to selectively reduce fat while increasing muscle by utilizing cutting-edge artificial intelligence (AI) and structural modeling technology internalized in the R&D center.” He added, “It treats obesity as a stand-alone treatment.” “It has infinite potential value in that it presents a new paradigm and shows quantitatively and qualitatively excellent weight loss effects even in combination with existing treatments,” he explained. He added, “As it was developed as a peptide-based material, we expect it to be price competitive compared to antibody modality-based muscle preservation treatments.”
At this conference, Hanmi Pharmaceutical presented two posters showing the results of non-clinical studies confirming the quantitative and qualitative improvement efficacy of HM17321 in weight loss and differentiated development strategies.
HM17321 is designed to selectively reduce fat and increase muscle at the same time by targeting the ‘CRF2 (Corticotropin-Releasing Factor 2) receptor’ rather than incretin receptors such as GLP-1.
Currently released GLP-1-based obesity treatments show an effective weight loss effect of 15 to 20%, but there is a limitation in that up to 40% of the weight lost is due to muscle loss. Additionally, due to the mechanism of action that suppresses appetite, side effects such as decreased basal metabolic rate and fat accumulation (yo-yo effect) may occur when the drug is discontinued.
When HM17321 is administered in an obese animal model, Hanmi Pharmaceutical shows a similar weight loss effect as semaglutide (Wegobi), a GLP-1-based drug, but also has differentiated efficacy in increasing lean mass and muscle mass. We introduce the confirmed results this time.
In particular, as a result of evaluating muscle function through a wire hanging test in an obese animal model, it was confirmed that HM17321 monotherapy had the effect of restoring muscle function to the levelof normal animals. In addition, Hanmi Pharmaceutical confirmed that administration of HM17321 in fat cells simulating obesity promoted lipolysis and improved the phenotype of fat cells to a normal level. It was proven that HM17321 acts directly on human muscle cells, contributing to quantitative and qualitative improvement of muscles.
In another presentation, HM17321 showed a significant reduction in body weight and fat mass as well as protection against inevitable loss of lean mass in combination with the next-generation obesity treatment triple agent (LA-GLP·GIP·GCG, HM15275) and semaglutide compared to each monotherapy. It was reported that it showed.
The results confirmed the possibility of HM17321 being developed as a ‘first-in-class new drug’ that can improve the quality of weight loss through fat-specific weight loss, increase in muscle mass, and improvement in muscle function, as a monotherapy treatment. Hanyi Pharmaceuticals emphasized that it has proven that it has differentiated competitiveness in both combination therapy and combination therapy.
Hanmi Pharmaceutical also presented a poster at this conference on the results of a follow-up non-clinical study of HM15275, which received a lot of attention when it was first unveiled at the American Diabetes Association (ADA) last June. HM15275 is a next-generation obesity treatment triple agent that can be expected to achieve a weight loss effect of more than 25% while minimizing muscle loss. Additionally, it is designed to be effective in various metabolic diseases. HM15275’s phase 1 clinical trial is progressing smoothly in the United States. The goal is to enter phase 2 clinical trials next year.
Choi In-young, head of Hanmi Pharmaceutical R&D Center, said, “This year, Hanmi Pharmaceutical is a leader in the HOP project and has established a leading position in the field of obesity treatment by successively announcing ‘HM15275’, a next-generation triple agent for obesity treatment that will continue the innovation of efpeglenatide, and HM17321, a new concept obesity treatment drug, at global conferences. “It was firmly established,” he said.
Meanwhile, Hanmi Pharmaceutical plans to hold ‘Hanmi Pharm Innovation Day’ at the Fairmont Ambassador Grand Ballroom in Yeouido, Seoul on the 11th and introduce the achievements and competitiveness of the HOP project, including new drugs for obesity. Representatives from each field, including Hanmi Pharmaceutical CEO Park Jae-hyun, Domestic Business Division Head Park Myeong-hee, New Product Development Division Head Kim Na-young, Global Business Division Executive Director Shin Hae-gon, and R&D Center Director Choi In-young, will attend to provide a detailed explanation of Hanmi Pharmaceutical’s business status, future innovation strategy, and R&D capabilities. plan.
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It seems you have provided a detailed report about a new drug regimen being developed by Hanmi Pharmaceutical for obesity treatment. Here’s a summary of the key points:
Summary of Hanmi Pharmaceutical’s Research on HM17321 and HM15275
- HM17321:
- Confirmed effectiveness in restoring muscle function to normal levels in animals.
– Promotes lipolysis (the breakdown of fats) in fat cells that simulate obesity, resulting in a more normal fat cell phenotype.
– Directly acts on human muscle cells to improve both the quantity and quality of muscle.
– In combination with a next-generation obesity treatment (HM15275) and semaglutide, significant reductions in body weight and fat mass were observed, alongside protection against lean mass loss compared to monotherapy.
- Potential as a First-in-Class Drug:
– HM17321 has shown promise as a monotherapy that can enhance weight loss quality by specifically targeting fat loss, while also increasing muscle mass and improving muscle function.
– Hanmi Pharmaceutical emphasizes its competitiveness in both monotherapy and combination treatments.
- HM15275:
– A next-generation triple-agent treatment for obesity shown to induce over 25% weight loss while minimizing muscle loss.
– Demonstrated effectiveness in addressing various metabolic diseases and currently undergoing phase 1 clinical trials in the U.S., with plans to start phase 2 trials next year.
- Leadership and Future Plans:
– Choi In-young, head of Hanmi Pharmaceutical’s R&D, emphasizes the company’s leading position in obesity treatment.
– The firm has consistently presented innovative drug developments at global conferences.
- Upcoming Event:
– Hanmi Pharmaceutical is set to hold an ”Innovation Day” to showcase their HOP project achievements, including the new obesity treatments, with key leadership in attendance to discuss the firm’s future strategy and R&D capabilities.
Conclusion
Hanmi Pharmaceutical is making significant strides in the development of obesity treatments, particularly with HM17321 and HM15275, which appear to offer innovative approaches to weight loss and muscle preservation. Their ongoing research and upcoming presentations reflect the company’s commitment to leadership in this field.