At present, there is the emergence of new subspecies of the Omicron virus. come out continuously including subspecies BA.4/5 and BA.2.12.1 that cause the epidemic of COVID-19 new wave in many countries around the world as well as concerns about resistance to immunizations derived from vaccination. and immunity derived from innate infections from subspecies BA.1 from previous outbreaks, the New England Journal of Medicine (June 30, 2022) has published a study from Ohios University researchers. State united states to assess the level of immunity in suppressing various subspecies of Omicron virus. Among healthcare professionals who received two primary mRNA vaccinations and three mRNA vaccinations, the researchers also studied the efficacy of inhibiting O. The new subspecies Micron was also among 30 hospitalized patients who were infected with Omicron strain during the BA.1 outbreak.
The study found Immunity to omicron subspecies Levels were low among healthcare workers who received two primary mRNA vaccinations for the coronavirus. Mean levels of immunity were 52, 39, and 37 against BA.1, BA.2 and BA.4/5 strains, respectively, demonstrating the ability to evade immunity of omicrons. The 3rd dose of mRNA booster vaccine (the sample was Four healthcare workers who received three doses of mRNA-1273 vaccine and 11 patients who received three doses of BNT162b2 vaccine) found that immune levels inhibited against various omicron-type strains were measured. greatly increased The mean levels of immunity from three doses of mRNA vaccination were 976, 933, and 647 against BA.1, BA.2 and BA.4/5 strains, respectively. Three doses of mRNA vaccine were still at lower levels compared to the original viral strain.
In addition, antibodies were assessed in 30 patients who had been infected with Omicron from the BA.1 wave and were hospitalized. but did not receive treatment in the ICU. The levels of immunity against BA.4/5 and BA.2.12.1 were 37.8% and 10.2% lower than those against BA.2 strains, respectively, indicating that immunity was obtained during the BA wave infection. .1 cannot provide effective protection against emerging subspecies of omicrons.
In conclusion, this research demonstrates the importance of booster vaccination in preventing and dealing with emerging virus strains. This can be seen from the booster vaccine boosting levels of immunity against omicron substrains BA.4/5 and BA.2.12.1, albeit at lower levels compared to Immunity to BA.1 and BA.2
data source
Qu, Panke et al. “Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants.” The New England journal of medicine vol. 386,26 (2022): 2526-2528. doi:10.1056/NEJMc2206725
