A meaningful discovery has been made that brings us one step closer to the human dream of living a long and healthy life. A specific gene that plays an important role in extending life span in various species, including humans, has been discovered.
Researchers at the University of Copenhagen’s Department of Cellular and Molecular Medicine and the Center for Healthy Aging in Denmark have discovered that a specific protein called OSER1 has a major impact on longevity.
According to a recent study published in the international academic journal Nature Communications, OSER1 encodes a new longevity-promoting factor.
“We have identified this protein that can extend lifespan. It is a novel longevity factor that is present in many animals, including fruit flies, nematodes, silkworms, and humans,” study lead author Professor Lene Juel Rasmussen said in a press release.
The researchers discovered OSER1 during their study of a larger group of proteins regulated by the FOXO transcription factor, known as a key regulator of longevity, and concluded that because the protein is present in a variety of animals, it may also apply to humans.
“We found 10 genes whose expression was altered to alter lifespan. We decided to focus on one of the genes with the greatest influence on lifespan, OSER1,” said Zhiquan Li, a postdoctoral researcher.
“We initially screened for potential longevity proteins that exist in many organisms, including humans, because if a gene exists only in an animal model, it can be difficult to apply it to human health. Ultimately, we are interested in identifying human longevity genes that are potentially intervenable and for drug development,” he explained.
This discovery is expected to open a new chapter in the development of new treatments targeting age-related diseases.
According to the medical media outlet Medical Xpress, if a gene is associated with a shortened lifespan, the risk of premature aging and age-related diseases increases. Therefore, knowledge of how OSER1 functions in cells and preclinical animal experiments is essential for comprehensive knowledge of human aging and human health in general.
“We are currently focusing on elucidating the role of OSER1 in humans, but it is challenging because there is little literature on this topic. This study is the first to demonstrate that OSER1 is a key regulator of aging and longevity. We hope that in the future, it will provide insight into specific age-related diseases and the aging process that OSER1 affects,” added Dr. Lee.
The research team expects that the identification and characterization of OSER1 will lead to the development of customized drugs for age-related diseases such as metabolic diseases, cardiovascular diseases, and neurodegenerative diseases.
With the aging population rapidly increasing, this discovery has the potential to extend lifespan and delay the onset of age-related diseases, making it a major achievement that could have a major impact on the health and quality of life of people around the world.
참고자료 FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species(
Reporter Park Hae-sik, Donga.com [email protected]
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2024-09-05 00:59:32