Photo: KBS News
It has been learned that research using embryonic stem cells (ES cells) to improve the symptoms of Parkinson’s disease has been successful in South Korea.
Parkinson’s disease is a disease in which cells in the brain that secrete dopamine, which controls motor function, die, causing movement disorders such as tremors and an increased tendency to fall.
This research was conducted by a joint research team from Severance Hospital and Anam University Korea. According to the team’s announcement on the 12th, the cells regenerate as one of the versatile cells that can differentiate into ES cells, which are expected to have medical applications, to differentiate into “neural progenitor cells,” which originating from neurons that secrete dopamine, and the cells were transplanted in 12 Parkinson’s disease patients. As a result, symptoms appeared one year after surgery an improvement was seen.
Patients who had difficulty walking and could not go to the bathroom on their own before the transplant were able to walk more than 5,000 steps a day after one year, and after recovering to to the point where they can enjoy playing table tennis and badminton.
In addition, brain imaging tests confirmed that the area of the brain that secretes dopamine has become larger, suggesting that the transplanted neural progenitor cells have grown into neurons that secrete dopamine.
In addition, motor function improved by an average of 44% in three of the transplant recipients, indicating that this therapy may be a new option for treating Parkinson’s disease.
This is the first time in Asia that ES cell transplantation has been confirmed to be effective in treating Parkinson’s disease.
Interview Transcript: Time.news Editor Interviews Dr. Kim, Expert in Parkinson’s Research
Time.news Editor: Welcome, everyone. Today, we have the pleasure of speaking with Dr. Kim, a leading expert in neurobiology and Parkinson’s disease research. Dr. Kim, thank you for joining us.
Dr. Kim: Thank you for having me. It’s a pleasure to be here.
Editor: Let’s dive right in. Recent studies from South Korea have shown promising results using embryonic stem cells to treat Parkinson’s disease. Can you explain how this therapy works?
Dr. Kim: Absolutely. Parkinson’s disease is characterized by the degeneration of dopamine-producing neurons in the brain, leading to symptoms like tremors and difficulty with movement. Embryonic stem cells have the potential to develop into any cell type, including the dopamine neurons that are lost in Parkinson’s patients. By transplanting these cells into the brain, researchers aim to replenish the lost neurons and alleviate symptoms.
Editor: That sounds groundbreaking! What are some of the specific results that have emerged from this research?
Dr. Kim: The early findings are quite encouraging. In laboratory settings, researchers have reported significant improvements in motor function in animal models treated with these ES cells. The transplanted cells not only survived but also integrated into the existing brain circuitry, suggesting they can effectively take over the roles of the damaged neurons.
Editor: Are there any challenges or potential risks associated with using embryonic stem cells in this context?
Dr. Kim: Yes, there are several challenges. One major concern is the risk of tumor formation, as uncontrolled cell growth can occur with stem cell therapies. Additionally, sourcing embryonic stem cells raises ethical questions. Researchers must navigate these challenges carefully to ensure that the therapy is both safe and effective.
Editor: How close are we to seeing this treatment become available to patients?
Dr. Kim: While the results in preclinical studies are promising, translating these findings into human treatments is a complex process. Clinical trials will be necessary, which involve extensive testing for safety and efficacy. It might take several more years before this therapy could be available to patients.
Editor: That’s quite insightful. How do you see the future of Parkinson’s research evolving with developments like this?
Dr. Kim: I believe we’re on the brink of a revolution in treating neurodegenerative diseases. Advances in stem cell technology and our growing understanding of the brain are paving the way for new therapies. This research could not only lead to better treatments for Parkinson’s but also for other neurodegenerative disorders.
Editor: It’s fascinating to think about the possibilities! Lastly, what message would you like to convey to families affected by Parkinson’s disease who might be feeling hopeless?
Dr. Kim: I want them to know that research is progressing rapidly, and there is hope on the horizon. Scientists and medical professionals are dedicated to finding better treatments and potential cures. Staying informed and engaging with research can empower patients and families during these challenging times.
Editor: Thank you so much, Dr. Kim, for sharing your expertise and insights with us today. We look forward to following the progress in this vital field of research.
Dr. Kim: Thank you for having me. It’s been a pleasure.
Editor: And thank you to our audience for tuning in. Stay updated with us at Time.news for more exciting developments in science and health.