Follow-up – WAA
A recent study has confirmed that lifestyle modifications can reduce the incidence of cardiovascular diseases, especially in individuals with a high genetic susceptibility.
The study, published by the “News Medical” website, highlighted the complex interaction between genetic predisposition and lifestyle choices in determining the risks of cardiovascular diseases among young people.
While rates of cardiovascular disease have stabilized or finally declined among older adults, there has been a worrying rise in the incidence of cardiovascular disease among individuals aged 15-49 years.
This demographic shift highlights the urgent need to address early cardiovascular health problems, which are influenced by genetic and environmental factors.
Genetic risk assessment through PRS scores derived from genome-wide association studies (GWAS) has been useful in predicting susceptibility to diseases such as coronary artery disease (CAD) in European populations, but its applicability to East Asian populations remains limited.
The study, conducted with participants from the China Kadoorie Biobank, focused on assessing how lifestyle factors interact with genetic predisposition to influence cardiovascular disease outcomes.
The group included more than 100,000 Chinese adults aged 30 to 79, who were selected based on their genetic profiles and absence of a history of previous heart attack or stroke.