2023-06-21 02:15:34
Updated Wednesday, June 21, 2023 – 02:15
Regarding the advance that revolutionized society a week ago, the Polish scientist stressed that “we are making embryos as structures for research and not as viable embryos”
Following the publication of her achievement in The Guardian, Polish scientist Magdalena Zernicka-Goetz is on everyone’s lips. She leads an international group of scientists from the University of Cambridge (United Kingdom) and the California Institute of Technology (USA), which has obtained synthetic human embryo models.
In an interview with EL MUNDO, via email, he apologizes for the response times because “the last 10 days were overwhelming and I’m sorry I wasn’t more efficient.”
Given the alarm generated by scientific progress and how it has been communicated to society, he insists that “I also want to emphasize that we are making embryos as structures and not as viable embryoswhich are imperfect, like all other models, but are very valuable in the field of research.”
What are the main differences between your embryoid proposal and that of the Weizmann Institute team? Both my team and the Weizmann Institute team use a common strategy that we first developed in mouse models by mixing three types of stem cells: embryonic stem cells that they can form any tissue; embryonic stem cells that have been modified to be like the extraembryonic cells that make up the yolk sac; and embryonic stem cells that have been modified to be like the extraembryonic cells that form the placenta. In these two new papers (studies) with models of human embryos, we use a different approach from that of the Weizmann team to convert these embryonic stem cells into these extra-embryonic types. It does not go into more detail because the work is pending publication in a scientific journal once may be reviewed by other scientists, right?Our paper will be published in a high level scientific journal but I am not authorized to say which one. There is no planned publication date yet. With the development of these models, whose research is restricted in some legislative frameworks, what can we expect in the short term to advance our knowledge of days of life? We have developed these models to understand the mechanisms of early development. There are about 30% miscarriages at this stage of development and we want to understand why. We cannot do experiments on natural human embryos so we have had to develop a model system. Our current work has allowed us to study the molecular mechanisms that cause the specialization (of the tissues) of the first forms of the embryo and has allowed us to characterize the formation of a tissue called amnion, which will lead to the formation of the sac that contains the amniotic fluid. . We have shown the factors that are essential for the formation of primordial germ cells – the progenitors of sperm and ova – and the essential signals for amnion tissue. The way in which the milestone has been made public has sparked much controversy. What are the obstacles this may have triggered? I have given several scientific conferences, but there were only reporters at the last one and the Guardian picked up the story. It is common to discuss unpublished work at conferences and is very useful for other scientists. Almost a year ago, when he presented the mouse embryo data in Nature, he called the move to humans “science fiction.” Were you already working on this? I’ve given several talks on this work and scientific conferences, but there were only reporters at the last one and the Guardian picked up the story. It is customary for scientists to discuss unpublished work at conferences. In fact, this is very useful for other scientists. Normally, however, the news is sent to the press after the release of an embargo by the magazine, which gives universities time to prepare a press release about the work. Almost a year ago, when I presented mouse embryo data in Nature, claimed that the passage to humans was science fiction. Was he already working on this? Why did you prefer to lower the expectations of being able to achieve it? The human embryo model that I am talking about has not gone as far in development as the mouse model. There are many things that the groups that are working on this have to improve. Either way, despite these shortcomings, we can begin to use these models to make new findings about development. Given the complexity of all the processes that occur in the conception of life, to what extent can we be faced with this approach? None of the mouse models develop when implanted in a mouse mother and to date there is a development blockade. of the models outside the mother (maternal womb). We will have to develop better ways of providing placental structures and a function for the development of the mouse system to go further. And the human system has a long way to go to get to where the mouse system has been. In “his hands” (embryonic models) are “the secrets of the first days” of human life, future disease and the complexity of abortive pregnancies. When might it be ready to be ‘read’, at least a small part? Our purpose is to carry out these experiments to find out something about this little-known phase of development in which many miscarriages occur. We hope that if we understand why this is happening, then we may be able to do something to prevent that loss of life. How long can that take? It is very difficult to predict.According to the criteria of The Trust Project
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