The French midfielder will be a substitute at the start of the round of 16 second leg.
Manchester United coach Ralf Rangnick decided to do without Paul Pogba at the start of the Champions League round of 16 second leg against Atlético Madrid on Tuesday, preferring young Anthony Elanga, scorer at the go (1-1).
Elanga and Jadon Sancho will surround Cristiano Ronaldo, author of a hat-trick last weekend against Tottenham (3-2) and on whom will rest a good part of Mancunian hopes, against an opponent he often mistreated when he played at the Real.
Bruno Fernandes, absent against Spurs, returns to lead the game, while Scott McTominay returns as a double pivot alongside Fred.
In defense, Raphaël Varane and Harry Maguire are associated in the axis, with Diogo Dalot on the right and Alex Telles on the left.
On the side of the Rojiblancos, the composition at kick-off is the most classic given the absences, in 3-5-2, with a formidable attack composed of Joao felix and Antoine Griezmann which relegates Luis Suarez to the bench.
Koke will be present to lead the game, as well as Jose Gimenez in defense, while he was uncertain before the match.
Manchester United: De Gea-Dalot, Varane, Maguire, Telles-Fred, McTominay-Sancho, Fernandes, Elanga-Ronaldo
Coach: Ralf Rangnick (GER)
Atlético Madrid: Oblak – Savic, Giménez, Reinildo – Llorente, Herrera, Koke, De Paul, Lodi – Joao Felix, Griezmann
Coach: Diego Simeone (ARG)
Referees: Slavko Vincic (SVN)