Today (27 March 65) the page of the Medical Genome Center, Ramathibodi Hospital, Mahidol University, asks questions about how many hybrids of the corona virus 2019 are there now. And which species are most worried by “5” answers that will help people understand the The recombinant lineage of COVID-19 has increased as follows:
Coronavirus 2019″, how are hybrids formed?
When viruses of similar species “Two strains”, such as delta and omikron, or omikron subspecies BA.1 and BA.2, multiply in the same cell. (coinfection) The activity that the virus performs immediately when it enters the cell. is to increase the number of offspring Viral enzyme responsible for creating new genomes Using the genome of the first species as a template, the process of creating a new genome went wrong for some time and it failed. In other words, the enzyme switched to the genome of the second species as a model to complete the genome (template switching) to complete. Resulting in a virus (genome) hybrid between the two species.
Why were so many hybrid species discovered during this period?
Because of the reports that a large number of hybrids from around the world were found during this period. It’s because we just have a virus that’s genetically different on the genome. It spreads simultaneously around the world, such as the “delta” strains BA.1 and BA.2, when hybrids between these viruses occur. We can easily screen these hybrids. Even though the genome’s shunt is small, Another reason is that outbreaks of BA.1 followed by BA.2 (in Europe and the US) occurred while there were also very high delta outbreaks- the potential for infection. join resulting in hybrid species
coronavirus 2019 hybrid strain How many species are there?
Coronavirus 2019 strain determination is based on COVID-19 strain code information. The entire genome submitted into the online program PANGOLIN divided the hybrids into 2 categories of 8 strains.
Category 1 Hybrids between “Delta x BA.1” consist of 2 members.
XD- is a cross between the Delta x BA.1 lineage found in France and contains the S gene that produces spikes. The other part is the genome from the delta.
The XF-genome is a mixture of S gene and key protein particle protein gene, derived from BA.1 and part 5′ from the delta genome.
Category 2 Hybrids between BA.1XBA.2 consist of 6 members.
XE-found in England The genome is a mixture of S gene and key protein particle protein gene from BA.2 and part 5 from the genome of BA.1, showing a growth advantage over BA.2.
XG-found in Denmark
XH-found in Denmark
XJ-found in Finland
XK-found in Belgium
XL-found in England
Hybrids XG,XH,XJ,XK, and XL have a break point between BA.1 and BA.2 in the ORF1ab gene region.
Which coronavirus 2019 hybrid strains are of concern and should be monitored?
XD hybrids should be closely monitored. This species is found in France, Germany, the Netherlands and Denmark. The spiny genome is obtained from the omikron (BA.1), and the rest of the genome is from the delta. If inbreeding In theory, recombination could cause a species to spread rapidly. and causing more severe disease than any species we’ve ever known But real-world data has yet to find that XD is a fast-spreading and severe COVID-19 outbreak. However, as a precaution, it should be closely monitored.
XF, XE, XG,XH,XJ,XK, and XL hybrids have immune evasion. the ability to spread Symptoms of the severity of coronavirus Looking at the genetic code on the genome, many experts agree that it is unlikely to differ from the Omikron (BA.1 and BA.2).
to know the types of hybrids for what
The emergence of hybrids poses a risk of progressive mutation which may affect the control of the outbreak ATK PCR screening, vaccine prophylaxis. And with antiviral treatment and synthetic antibodies, we need to know that we are fighting the COVID-19 virus. Which species mutated in detail